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Senior Research Associate/Research Associate - Analytical Development

Employer
ReCode Therapeutics
Location
Menlo Park, California
Start date
Mar 10, 2023

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Job Details

Who We Are:

We are a clinical stage company powering the next wave of genetic medicine through superior delivery with our next-generation lipid nanoparticle delivery platform. Our mRNA and gene editing therapeutics have the potential to directly replace or address underlying genetic mutations in a vast range of diseases starting with primary ciliary dyskinesia and cystic fibrosis. Our selective organ targeting (SORT) LNP platform is uniquely differentiated to enable the delivery of diverse genetic payloads to tissues beyond the liver.


At ReCode, we bring a unique blend of rigor, creativity, and curiosity to our high-hurdle mission. Our team is uniquely positioned to tackle this challenge, given our extensive experience in lipid nanoparticle delivery, mRNA design and optimization, mRNA manufacturing, gene editing, and rare disease drug development. We are a high performing, highly functional organization with a culture that is caring and strives to enable every member of our team to thrive.


Responsibilities:

  • Develop and validate analytical methods for the characterization and quality control of LNPs-mRNA process and formulation development.
  • Prepare various biological matrices (e.g. plasma, whole blood, and tissue samples) for Liquid Chromatography-Mass Spectrometry (LC-MS) analysis and optimize sample preparation protocols.
  • Analyze biological samples using LC-MS methodologies and perform data analysis/interpretation for both qualitative and quantitative analysis.
  • Author analytical methods, protocols, reports and other documents as appropriate.
  • Coordinate with general analytical laboratory activities including equipment maintenance, ordering lab supplies and performing lab clean up on a routine basis.
  • Work closely with process and formulation teams to coordinate sample processing and testing to support R&D through late phase product developments.
  • Coordinate method development, validation and transfer activities at CRO or CDMO and review analytical documents and testing data as appropriate.


Qualifications:

  • MS or BS with 1+ years relevant industry experience preferably in an analytical development or QC environment.
  • Hands-on experience with HPLC, UPLC, LC-MS and various analytical techniques is a must. Extensive hands-on experience on the analysis and characterization of mRNA and lipids is preferred.
  • Experience with biological sample handling and preparation (e.g. whole blood, plasma, tissue), including tissue homogenization, liquid-liquid extraction, and solid-phase extraction.
  • Track record of analytical method development, troubleshooting, optimization, validation and transfer preferably under GMP environment.
  • Attention to detail and excellent skills in Microsoft Office and data analysis software (e.g., Empower, ChemStation, Chromeleon, etc.) and other applications.
  • Must be comfortable to work in a fast-paced, cross-functional environment and collaborate effectively with other team members.
  • Strong oral and written communication skills to support internal and external communications/presentations.


Salary Range: *

*70-100K - Please note that for remote positions, salary may be adjusted for cost of living


Benefits Offered:

  • No premium cost for employees - 100% subsidized by ReCode for full-time employees
  • Company 401k contribution
  • 15 days of company paid holidays, including a holiday shutdown (usually the last week of the year)
  • Mental health support for employees & their families
  • FSA available, including a lifestyle spending account subsidized by company
  • Employee discounts at hotspots


ReCode Therapeutics (www.recodetx.com) offers a competitive compensation/benefits package with a friendly, collaborative culture that values employee engagement and ongoing career development.


ReCode Therapeutics is an Equal Opportunity Employer.

Company

The Why Behind Our Work

We imagine a world where people living with genetic diseases can fully benefit from the promise of genetic medicines. Our novel mRNA and gene correction therapeutics have the potential to make this a reality.

Therapeutic Areas of Focus

Cystic fibrosis

Primary ciliary dyskinesia

Certain cancers and central nervous system (CNS) diseases

Power the Next Wave of Genetic Medicine

We are one of the rare companies whose innovations are poised to fundamentally shift an entire class of medicine.

Join us as we advance our pipeline into clinical development and scale ReCode’s next-generation genetic medicines delivery platform and pipeline.

Company info
Website
Phone
408-585-1700
Location
1140 O'Brien Drive
Menlo Park, CA 94025
US

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