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Research Associate, RESEARCH: T CELL IMMUNOLOGY, CAR T CELL

Employer
Adicet Bio, Inc.
Location
Redwood City, CA
Start date
Mar 10, 2023

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Discipline
Regulatory, Science/R&D, Research, Immunology
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Biotech Bay

Job Details

 

JOIN US!

Adicet Bio, Inc. is a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for cancer. Adicet is advancing a pipeline of “off-the-shelf” gamma delta T cells, engineered with chimeric antigen receptors (CARs) and adaptors (CAds), to enhance selective tumor targeting and facilitate innate and adaptive anti-tumor immune response for durable activity in patients. For more information, please visit our website at https://www.adicetbio.com.

 

Research Associate, RESEARCH: T CELL IMMUNOLOGY, CAR T CELL

We are seeking a highly motivated candidate with a background in immunology to join the Adicet Research Team. The ideal candidate will have in-depth knowledge of T cell immunology and CAR-T cell development. The candidate will work as a part of a multidisciplinary team, utilizing the latest technologies for cell engineering and contributing to the generation of novel cell-based therapeutics for the treatment of cancer.

 

Responsibilities:

  • Carry out genetic modifications of gd T cells using both viral and non-viral methods.
  • Cell culture (primary cells, cancer cell lines, CAR-T cells) for cell-based assay development (proliferation, cytokine release, cytotoxicity).
  • Design, perform, and analyze in vitro experiments to characterize CAR-T cell function.
  • Apply nucleic acid, protein, and reporter-based technologies (e.g., Nanostring, Luminex, Incucyte) for assay analysis.
  • Perform multi-color flow cytometry (cell surface/intracellular staining, cell sorting)
  • Maintain detailed records of experimental protocols, results, and inventory in an electronic lab notebook.
  • Analysis and interpretation of experimental data.
  • Present at group meetings.
  • Utilize software tools to support data analysis tasks (e.g., Prism, FlowJo, Word, Excel and PowerPoint).

 

Qualifications:

  • BS or MS/MSc in biological sciences or a related field.
  • 1 to 3 years of relevant academic and/or industry experience.
  • Experience in primary cell culture and aseptic tissue culture techniques is required.
  • Experience with cell-based assays (e.g., CAR-T and cancer cell co-culture, cytotoxicity, cytokine, proliferation, and serial stimulation assays).
  • Experience with multicolor flow cytometry and data analysis on FlowJo is a plus.
  • Viral and non-viral gene-editing on primary T cells or NK cells experience is preferred.
  • Ability to work collaboratively, multitask and meet deadlines in a fast-paced environment.
  • Openness to flexible working hours is preferred.
  • Organized and disciplined record keeping is essential.
  • Team player with excellent verbal and written communication skills

At Adicet, our people are our greatest focus. We believe that attracting and retaining the best and brightest is the key to achieving our mission to deliver best-in-class gamma delta T cell therapies for patients fighting cancer.

We offer a competitive compensation package including base salary, annual cash bonus, long-term incentives (equity), Employee Stock Purchase Plan (ESPP) and a 401(k) with ROTH and a 4.5% Company match.

To ensure the wellness of our employees and their loved ones, we offer comprehensive health plans (medical, dental, vision, etc.), Flexible Health and Commuter Spending Accounts (FSA) and a company matched Health Savings Account (HSA). We also offer a life, AD&D, short and long-term disability insurance, and legal, pet, and various other voluntary insurance programs.

We also believe our greatest ideas come when we are refreshed and focused, and we offer generous paid time-off including 12 company holidays with end-of-year shutdown, vacation, sick time, and paid parental leave.

Adicet is located in a state-of-the-art facility and works to create an incredible office experience with an onsite gym and various other fitness options, abundant, zero-cost, onsite parking with electric vehicle charging stations and free shuttle (Caltrain), company subsidized lunches (delivered onsite daily) and fully stocked breakrooms.

In compliance with California’s pay transparency law and in pursuit of pay equity and fairness, we publish salary ranges for all open positions. The pay scale range for this role is $83,000.00 - $115,000.00 annualized base salary. The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to, their qualifications (education, experience, specialty, and training), and peer and market data. This listed salary range represents the Company’s good faith and reasonable estimate of the range of possible compensation at the time of posting.

Company

Adicet Bio, Inc. is a privately held, pre-clinical stage biotechnology company developing novel universal immune cell therapies based on gamma delta T cells engineered with Chimeric Antigen Receptors.  Adicet is also focused on identifying and validating cancer specific targets directed to the intracellular proteome and then generating T Cell Receptor-like monoclonal antibodies (TCRLs) directed to these cancer-specific peptide targets presented by MHC Class I complexes. These TCRLs are being used to arm T cells or as T cell engagers in solid tumors. In August 2016, Adicet entered into a strategic collaboration with Regeneron Pharmaceuticals, Inc. to develop next-generation engineered immune-cell therapeutics using Adicet's gamma delta T cell allogeneic platform technology.
 
For more information, please visit our website at http://www.adicetbio.com.

Company info
Website
Location
1000 Bridge Parkway
Redwood City
California
94065
United States

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