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Vice President - Head of Non-Clinical Development

Employer
Black Diamond Therapeutics, Inc.
Location
Cambridge, MA
Start date
Mar 10, 2023

View more

Discipline
Clinical, Clinical Development, Clinical Research
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Genetown

Job Details

Overview

Black Diamond Therapeutics is a precision oncology medicine company pioneering the discovery and development of small molecule, tumor-agnostic therapies. Black Diamond targets undrugged mutations in patients with genetically defined cancers for whom limited treatment options currently exist. Black Diamond is built upon a deep understanding of cancer genetics, protein structure and function, and medicinal chemistry. The Company’s proprietary technology platform, Mutation-Allostery-Pharmacology, or MAP, platform, is designed to allow Black Diamond to analyze population-level genetic sequencing data to identify oncogenic mutations that promote cancer across tumor types, group these mutations into families and develop a single small molecule therapy in a tumor-agnostic manner that targets a specific family of mutations.

 

The VP of Nonclinical Development leads Black Diamond Therapeutic’s research and early development non-clinical studies through early clinical development. Non-clinical studies relate to Preclinical Toxicology, Pharmacology, DMPK supporting IND readiness for pipeline candidates. This leader will contribute to fostering our culture of innovation, as well as strategi c and scientifically sound approaches for advancing novel therapies. They will work closely and collaborate with leaders across the Company including; Discovery Chemistry and Biology, Clinical Development, Clinical Operations, Program Leadership and Management, Business Development, CMC, Translational Medicine, and Regulatory groups.

Responsibilities

• Ensure the selection and successful transition of small molecule development candidates into clinical assets through the strategic scoping and curation of nonclinical study packages supporting safety, toxicology, & pharmacokinetics that enable clinical exploration of novel therapeutics.• Oversee established internal teams of in vivo and ex vivo scientists and coordination of networks of external CROs as key resources for study development and execution.• Support drafting of regulatory filings in collaboration with BDTx’s Program Leadership and Management, Regulatory and Development Operations group and the strategic curation and delivery of key content for nonclinical sections of INDs/CTAs and related NDAs/BLAs• Contribute to key interactions with regulatory agencies as the representative for nonclinical science (responses to queries, preparation of pre-meeting documents, attend teleconferences and meetings with Health Authorities, as needed)• Contribute to cross-disciplinary Research Leadership Team through portfolio prioritization in conjunction with other research leadership peers• Mentor scientists and actively promote a culture of enriching personal, professional, and organizational development• Communicate key program risks and potential solutions to R&D leadership and to the executive team in a transparent and timely manner

Qualifications

• PhD or MD/PhD degree in chemistry, biochemistry, pharmacology, pharmaceutical science, toxicology, veterinary pathology, or other closely related discipline is required.• 10+ years of experience pertaining to IND enabling activities and related disciplines, with a minimum of 5+ years applicable experience in field of small molecule therapies.• Requisite and evidenced expert contributions and broad experience in executing and curating summaries for module 4 related studies for successful IND/NDAapplications.• Established capacity to oversee and guide focused and efficient study execution efforts to achieve meaningful outcomes supported by scientific integrity and innovative value• Demonstrated scientific leadership experience, including demonstrated capacity to develop and mentor others• Self-motivated, creative, and focused; able to work within a team and to collaborate with colleagues to achieve program goals• Strong quantitative skills and ability to represent the interpretation of non-clinical data to early discovery and clinical development project teams and to health authorities• Excellent interpersonal, verbal, and written communication skills• Strong people management skills and ability to build, influence, and lead a team• An outstanding track record of scientific accomplishments spanning the field as demonstrated through scientific publications, presentations, patents, and contributions to nonclinical/translational peer groups or consortiums

Company

Our Vision
Precision Cancer Medicines for Every Genetically-Defined Patient    
 
Company Overview
Black Diamond Therapeutics: A Next-Wave Cancer Precision Medicine Company
 
Black Diamond Therapeutics has pioneered the development of selective medicines for patients with genetically-defined cancers driven by oncogenes activated by allosteric mutations.
 
The cornerstone of our approach derives from evolving trends in cancer clinical medicine. Genome-wide information – now routinely obtained from DNA testing of cancer patients – identifies clusters of uncharacterized genomic alterations. Today, new baskets of un-drugged oncogenic targets exist, leading to the identification of additional cancer patients in need of novel therapies.
 
Using our MAP platform, Black Diamond Therapeutics is pioneering new ways to functionally assess the mutational landscape of individual oncogenes – to discover and validate new targets, and to develop novel approaches to creating highly selective therapeutics.

Company info
Website
Location
One Main Street
Cambridge
MA
02142
United States

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