Principal / Senior Scientist, Nucleic acid delivery

ABOUT GREENLIGHT

At GreenLight we are working to solve two of the world's greatest problems: global food insecurity and equal access to vaccines and the associated health benefits. Unlike most corporations who can be required to put profits ahead of other principles, GreenLight is one of the first Public Benefit Corporations to be publicly traded and have a charter that requires a focus on how it benefits its employees, community and society and has a broad portfolio addressing key issues in plant health and human health (Nasdaq: GRNA) by leveraging the full potential of dsRNA and mRNA. The GreenLight team is a  little over 260 people across our headquarters in Lexington, MA, an R&D facility and an R&D facility in Research Triangle Park, NC. GreenLight also has a biomanufacturing plant in Rochester, NY. Initiatives include finding ways to support biodiversity, protect bees and other pollinators, treat rare diseases as well as develop vaccines.

At GreenLight, we believe inclusion is the way forward. We celebrate the power of working together to address humanity’s challenges, meet the needs of underserved populations, and push the boundaries of scientific discovery. Fueled by our aspiration for a true sense of belonging, our talented teams embody the principles of diversity and equality as we strive to bring food security, medicine, and healthcare to everyone—paving the way for a sustainable future. For more information, visit www.greenlightbio.com.

POSITION SUMMARY

GreenLight Biosciences is seeking a highly motivated and experienced Scientist to join the CMC Drug Product Development team. This role is an exciting opportunity to develop new LNP-mRNA formulations to help advance the company’s pipeline and RNA platform technology. The candidate must have a strong background and understanding in nucleic acid delivery, preferably with mRNA-LNP formulations.  Experience with drug delivery and general biopharmaceutical sterile drug product development is highly desirable.

MAJOR RESPONSIBILITIES

• Design, coordinate, execute and analyze nucleic acid delivery formulations for multiple disease applications, including vaccines and gene therapies.
• Develop appropriate analytical methods in collaboration with analytical development scientists to develop and characterize novel formulations.
• Develop nucleic acid encapsulation strategies, including scale-up of mixing and further processing from bench scale to GMP manufacturing scale.
• Work as part of an integrated multidisciplinary team developing novel formulations and delivery.
• Employ statistical analysis of data in experimental reports and data summaries.
• Communicate research and development findings internally and externally.

PROFESSIONAL EXPERIENCE / QUALIFICATIONS

• Ph.D. in chemistry/chemical engineering, biochemistry/biophysics, pharmaceutical chemistry, or a related field with 5+ years of experience.
• Preference will be given to candidates with experience in nucleotide delivery.
• Strong background in biochemistry, biophysics, or pharmaceutical chemistry
• In-depth knowledge of optimizing cellular uptake, endosomal release and translation,  including tissue targeting are highly desirable.
• High-throughput screening experience and, design of experiment, Strong data analysis and experimental design skills, experience with JMP is a plus.
• Track record of creative problem-solving skills to troubleshoot experimental challenges.
• The successful candidate must take accountability and possess strong communication skills, strong organizational skills, and a commitment to team success.
• Ability to collaborate in a dynamic and fast-paced environment while prioritizing and handling multiple projects or activities. 
• Must be curious, open to learning, able to work independently and collaboratively.
• Experience with good documentation practices, good laboratory practices and an understanding of quality control practices/strategies is highly desired.

Greenlight Biosciences Inc. provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.

GreenLight requires proof of COVID-19 vaccination for its employees.