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Senior Scientist, Medicinal Chemistry

Nurix Therapeutics
San Francisco, CA
Start date
Mar 3, 2023

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Science/R&D, Biotechnology, Chemistry
Required Education
Position Type
Full time
Biotech Bay

Job Details

We are seeking talented and highly motivated individuals with a strong background in synthetic organic chemistry to join our medicinal chemistry group in the pursuit of novel small molecules to treat patients with unmet medical needs. The successful candidate will engage in rational structure-based drug discovery enabled by our computational and structural biology group. Specifically, this individual will design and synthesize novel chemical entities optimized for potency, selectivity, pharmacokinetics, and in vivo efficacy. As a member of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix and with external collaborators. Additionally, they will contribute effectively to patent, report, and scientific publication writing.


  • Ph.D. in synthetic organic chemistry with 6+ years of pharmaceutical medicinal chemistry industrial experience
  • Successful application of structure-based drug design leading to advanced leads/ development candidates. Strong working knowledge of protein-ligand interactions, and conformational and structural analysis, experienced in partnering closely with computational chemists through the appropriate use of computational tools, models, and visualization applications
  • High level of creativity and productivity with strong synthetic problem-solving skills
  • Excellent scientific expertise in organic synthesis, conversant with the current literature
  • Ability to champion chemistry efforts in new directions to achieve project milestones
  • Solid track record of innovation and impact on programs, with direct contributions to company pipelines (including both successful advances and smart terminations)
  • Proven leadership capability in a cross-functional team setting, either as a project team leader or co-lead
  • Strong evidence of conceptual thinking and active follow-through, recognized by establishing new projects or new directions within projects, new strategies, and/or enabling technologies for drug discovery
  • Vigorous scientific curiosity evidenced by contributions to diverse medicinal chemistry strategies
  • Ability to make inventive contributions towards new chemical target structures or templates for programs, and employ sound judgment in the evaluation and strategic decision-making around early screening or literature hits
  • Excellent knowledge of medicinal chemistry principles with a solid understanding of the basic biology and pharmacology of programs, the ADME issues, and series SAR. Able to effectively integrate this knowledge and apply the key principles of medicinal chemistry, literature precedent, and drug design to direct medicinal chemistry programs to phase transitions or series go/no-go decisions
  • Strong skills in gathering, documenting, and analyzing information from competitive sources such as patents and meetings and using this information to guide program strategy
  • Excellent communication skills and ability to present the rationale, key data, issues, and accomplishments of the chemistry efforts to other members of the department

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view


Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Find Us
1700 Owens Street
Suite 205
San Francisco

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