Sr. Research Associate/Scientist, Downstream Process Development

As a member of the Process Development, CMC group, the Sr. Research Associate/Scientist will contribute to the development and implementation of downstream purification processes to enable the advancement of Janux therapeutic candidates from Research through Clinical development. The successful job candidate will contribute to the development and technical transfer of purification processes to Contract Development and Manufacturing Organizations (CDMOs) for clinical manufacturing.

 

Essential Functions and Responsibilities:

• Design and perform experiments to identify and establish operating and performance parameters for purification steps and overall processes.
• Execute lab-scale process development and material generation activities to support pre-clinical studies and technical transfer to CDMOs.
• Perform experiments and interpret results to evaluate process parameters for individual unit operations.
• Prepare SOPs and technical reports and maintain appropriate records of experiments.
• Responsible for operation and preventive maintenance of laboratory equipment.
• Work under general supervision to ensure timely execution of projects.
• Analyze and communicate experimental results to colleagues and supervisor and provide solutions to problems.
• Collaborate across functional areas, maintaining a good rapport.
• Assist with protein inventory management.
• Other duties as deemed necessary.

 

 

Required Skills and Qualifications

• BS degree in Cell and Molecular Biology, Biochemistry, or a related discipline and the following number of years of experience depending on level;
  • Sr. Research Associate – 4 to 6 years with a BS or 2 to 4 years with a MS.
  • Scientist – 6 to 8 years with a BS, 4 to 6 with a MS, or 1 to 2 with a Ph.D.
• Skilled in chromatography and filtration unit operations.
• Experience with purification equipment including AKTA chromatography, normal-flow/virus filtration, and TFF/UFDF systems.
• Working knowledge of different modes of chromatography, types of resins, and column packing.
• Strong analytical skills with hands-on experience with protein analysis including SDS-PAGE, Western Blot, HPLC, and Octet.
• General understanding of cGMPs, and experience working CDMOs is a strong plus.
• Knowledge of mammalian protein expression is a plus.
• Ability to multi-task, prioritize projects, and troubleshoot process and equipment problems.
• Ability to work in a highly collaborative environment with rapidly evolving priorities.
• Excellent written and oral communication skills.

 

Compensation:

In addition to a competitive base salary ranging from $90,000 to $120,000, we offer stock options, a stock purchase plan (ESPP) and a target bonus.   Janux also provides a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance. Relocation assistance may also be available.

Please note that the base salary range is a guideline, and individual total compensation will vary based on factors such as qualifications, skill level, competencies, internal equity and work location.

 

Job Type: Full-time

Benefits:

• 401K
• Medical insurance
• Dental insurance
• Vision insurance
• Supplemental disability insurance plans
• Flexible schedule
• Life insurance
• Flexible vacation
• Sick time
• Incentive stock option plan
• Relocation Assistance

Schedule:

Monday to Friday

Work authorization:

United States (Required)

Additional Compensation:

Annual targeted bonus %

Work Location:

Onsite; San Diego, CA

 

EQUAL OPPORTUNITY EMPLOYER:

Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.

 

 

 

Janux Therapeutics is a clinical stage immuno-oncology company developing drugs for a variety of solid tumor cancers. Janux is leveraging its innovative and proprietary tumor-activated discovery platform to efficiently develop product candidates designed to generate tumor-specific immune responses to attack and kill tumors without destroying a patient’s healthy tissue.

As a biotechnology company based in San Diego, Janux is an active part of a vibrant and growing biotech ecosystem. We are looking for energetic and talented people with a desire to work in a fast-paced and dynamic team environment. We believe that the whole team contributes to the overall mission. We succeed as a team, and we grow as a team.

Notice to Recruiters and Third-Party Agencies

The Talent Acquisition team manages the recruitment and employment process for Janux. To protect the interests of all parties involved, Janux will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Janux employees directly in an attempt to present candidates. Janux will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees.