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Sr. Scientist 1, Analytical Development

Omeros Corporation
Seattle, WA
Start date
Mar 1, 2023

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Job Details

Sr. Scientist, Analytical Development


This position will focus primarily on method development and characterization in support of early and late-stage clinical development and commercialization of protein therapeutics (drug substance and drug product).



Good things are happening at Omeros!


Come join our Omeros CMC Team!


Who is Omeros?  

Omeros is an innovative biopharmaceutical company committed to discovering, developing and commercializing small-molecule and protein therapeutics for large-market and orphan indications targeting inflammation, immunologic diseases (e.g., complement-mediated diseases) and cancers. Omeros’ lead MASP-2 inhibitor narsoplimab targets the lectin pathway of complement and is the subject of a biologics license application pending before FDA for the treatment of hematopoietic stem cell transplant-associated thrombotic microangiopathy. Narsoplimab is also in multiple late-stage clinical development programs focused on other complement-mediated disorders, including IgA nephropathy, atypical hemolytic uremic syndrome and COVID-19. OMS906, Omeros’ inhibitor of MASP-3, the key activator of the alternative pathway of complement, is in a Phase 1 clinical trial. For more information about Omeros and its programs, visit .


What are your job responsibilities?


·        Method development and optimization of chromatographic (HPLC, UPLC, LC-MS) and/or electrophoretic (CE-SDS, icIEF, CE-MS) methods both internally and in partnership with CROs and CMOs

·        Support tech transfer to CROs and CMOs and oversee qualifications and/or validations of analytical methods

·        Lead and/or support stability studies and formulation development

·        Identify and evaluate new, orthogonal and complimentary technologies that expand and improve technical capabilities, efficiency, and throughput within the group

·        Provide scientific and technical leadership to junior staff members to ensure project deadlines and performance standards are met

·        Represent Analytical Development in project team meetings; collaborate closely with management to set priorities and reach objectives


Education, Skills and Knowledge


·        Requires a PhD in Biochemistry, Chemistry, Analytical Chemistry, or a related field with 3 + years; a MS degree with 8+ years, or a BS degree with 10 + years of biotechnology and pharmaceutical industry experience will also be considered  

·        Proven technical leadership and strong understanding of principles of chromatographic and/or electrophoretic separation techniques

·        Experience characterizing physicochemical and biological properties of monoclonal antibodies, including knowledge related to chemical and post-translational modifications, degradation pathways, etc.

·        Experience developing robust HPLC (SEC, RP, peptide map, CEX, etc.), CE (CE-SDS, icIEF) and/or LC-MS methods

·        Demonstrated experience creating analytical development plans and experiment design, generation of test procedures, qualification/validation, and establishing product specifications and critical quality attributes and limits

·        Experience working with collaborative cross-functional teams including functional area representatives from Research, Process Development, Regulatory, QC, and QA

·        Familiarity with ICH, FDA and USP guidance

·        Demonstrated technical writing and verbal communications skills with peers and management

·        Experience supervising a small group (3-5) of junior staff members is a plus


Behavioral Competencies Required: 

·        Demonstrated capability of generating and interpreting data and communicating and presenting results to peers and management

·        Demonstrated ability to build and maintain positive relationships across functional areas and with management and peers

·        Demonstrated problem-solving and multi-tasking abilities

·        A track record of successfully managing activities and relationships and meeting timelines within an organization and in collaboration with external partners

·        Ability to work in a collaborative, fast-paced and dynamic team environment

·        Detail oriented, highly adaptable, proactive, and self-motivated


Physical Demands Required:

·        Intermittent physical activity including bending, reaching, pushing, pulling, or lifting up to 40 lbs. 

·        May encounter prolonged periods of sitting or standing

·        This position requires working around hazardous materials


Compensation and Benefits


Omeros is proud to offer a competitive total compensation package designed to support the lives of our employees and their families. The wage scale for this position is $125,000 to $145,000 per year.  Salaries will be determined based on knowledge, skills, education and experience relevant to the role.  Employees are offered medical, dental, vision and life insurance and a 401k plan with a company match.  Employees accrue three weeks of vacation and 80 hours of sick time on an annual basis and receive twelve paid holidays throughout the calendar year.  This position is eligible for bonus and stock options. To learn more about Omeros, please visit 


Omeros is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to status as a protected veteran or a qualified individual with a disability, or other protected status such as race, religion, color, national origin, sex, age, marital status, or any other factor determined to be unlawful by federal, state, or local statutes.

It is our policy to provide reasonable accommodation to anyone with a disability who needs assistance completing the job application process. If you need assistance, you can either send an e-mail to   or contact Omeros, asking for Human Resources, at (206) 676-5000



At Omeros, we are proud of our innovative and cutting-edge science. Our world-class team has achieved scientific advances that no other group has been able to accomplish, delivering wholly new classes of therapeutics to benefit patients. We let science lead the way.

From our foundation of groundbreaking science, we continue to build and advance a deep and diverse pipeline of small-molecule and protein therapeutics. We are not interested in developing “me-too” products; instead, we are focused on tackling challenging diseases and disorders with significant unmet medical needs. The result is an exciting pipeline of first-in-class drugs with new mechanisms of action that target previously untapped receptors and enzymes.

The Omeros team is exceptionally talented, passionate, collaborative and diverse. We hire smart, creative and hard-working people who want to play a meaningful part in building a preeminent biopharmaceutical company. We come from all corners of the globe, bringing unique abilities and experiences together to provide hope to patients and their families.

Find Us
201 Elliott Avenue West

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