Research Scientist- Discovery Sciences and Technologies

Research Scientist- Discovery Sciences and Technologies
United States - California - Foster City

Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead’s therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.

Making an impact on a global scale
Inclusion is one of the company’s five core values. That’s because we know that we are stronger and more innovative at Gilead when we are informed by a diverse set of backgrounds, experiences and points of view. Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide.

When you join Gilead, you join our mission to change the world by enabling people to live healthier and more fulfilling lives. Come join a mission-driven bio-pharmaceutical organization that values inclusion and diversity, has a strong portfolio of products, and is constantly #CreatingPossible

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Please log onto your Internal Career Site to apply for this job.

At Gilead we believe every employee deserves a great leader. As a people leader now or in the future, we expect that you will model and create an environment of inclusion, be intentionally focused on the hiring, development, growth and retention of talent, and empower teams to align and achieve goals.
Job Description


Position Overview:

We are seeking a highly motivated and creative Research Scientist to join the Discovery Sciences and Technologies (DST) Department and contribute to our biochemistry and cell biology capabilities to enable the identification and nomination of small molecule and biologics drug candidates across all therapeutic areas at Gilead.

DST Department members are responsible for the design and execution of rigorous, quantitative, and physiologically relevant in vitro biochemical and functional cellular assays. They collaborate within multi-disciplinary teams to discover and evolve drug candidates from lead identification efforts during project inception to the characterization of the final development candidate.

The successful candidate will be an integral member of the DST research team and work closely with various Research functions such as medicinal chemistry, structural biology and protein therapeutics to advance transformational therapies into clinical development for patients. Gilead is a highly matrixed organization and the ability to work effectively across diverse functional groups and therapeutic areas is a key attribute for this role.

Specific Responsibilities:

• Develop robust biochemical and cellular assays to measure drug efficacy, potency as well as functional activity.
  
• Perform automation enabled high-throughput screen to discover hit molecule and robust functional assays to support lead optimization across therapeutic modalities.
  
• Apply diverse in-vitro pharmacology methods and approaches to elucidate mechanisms of action of drug candidate on target proteins and cellular signaling pathways.
  
• Provide translational biological evidence in support of candidates moving toward clinical investigation
  
• Provide scientific insight and in-depth data interpretation to inform decision making at the project team and leadership levels.
  
• Apply cutting-edge chemical biology and functional genomic approaches to gain insights of fundamental biology in the in vitro setting and participate in the novel target validation effort when needed.
  
• Evaluate and implement new technologies to support advancement of internal programs and core group functions.
  
• May involve mentoring associates, providing scientific direction and guidance.
  
• Contribute to several projects at any given time, work successfully in a cross-functional team environment and communicate clearly both verbally and in writing to a variety of audiences.
  

Minimum Qualifications:

• Ph.D. in immunology, cell biology, biochemistry, or a related field
  
• 0 - 5 years of postdoctoral research experience with evidence of relevant publications
  
• In-depth knowledge and research experience in one of the following research fields: immunology, oncology, or virus-host interaction
  
• Well-versed in cell line development and primary cell culture, cellular signaling and developing biochemical and cell-based functional assays
  
• Solid proficiency in molecular biology and cell biology techniques such as PCR, RT-PCR, immunoblot, flow cytometry and common protein quantification methods (ELISA, MSD, Luminex, etc.)
  
• Experience in utilizing chemical or genetic perturbation to interrogate cellular phenotype, drug pharmacology and MOA with high-dimensional readout (e.g., single-cell RNA seq or high-content imaging) is preferred.
  
• Strong data processing and analysis skills, with familiarity with R or Python language for data analysis being a plus.
  
• Strong experimental design and troubleshooting skills, can document laboratory procedures and experiments with great attention to detail and the ability to multitask effectively in a dynamic fast-paced research environment.
  
• Strong verbal and written communication skills and effective interpersonal communication skills are essential.
  

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As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@gilead.com for assistance.

Following extensive monitoring, research, consideration of business implications and advice from internal and external experts, Gilead has made the decision to require all U.S., Canada, Australia, Singapore, and Hong Kong employees and contractors to receive the COVID-19 vaccines as a condition of employment. “Full vaccination” is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.​

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Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Gilead Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.






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