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Postdoctoral Fellow

Frederick National Laboratory for Cancer Research
Frederick, MD
Start date
Feb 28, 2023

View more

Clinical, Clinical Research
Required Education
Position Type
Full time

Job Details

Postdoctoral Fellow

Job ID: req2967
Employee Type: exempt full-time
Division: Applied & Development Research Program
Facility: Frederick: Ft Detrick
Location: PO Box B, Frederick, MD 21702 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.


The Laboratory of Human Retrovirology and Immunoinformatics (LHRI) is composed of three sections: the Basic, the translational, and the Bioinformatics research sections, and has collaborated with the National Institute of Allergy and Infectious Diseases (NIAID). LHRI has supported NIAID clinical studies for patients infected with HIV, HCV, SARS-Cov2, and other viruses. During studies, LHRI has discovered Interleukin-27 (IL-27) as an anti-viral protein, Ku70: a DNA repair protein, as a Type-III Interferon inducing cytosolic DNA receptor, and novel IL-27-inducing anti-viral micro RNAs (miRNAs). LHRI carried over the Database for Annotation, Visualization and Integrated Discovery (DAVID) ( from LIB and has maintained/ improved it to support users. The Basic research section is looking for a young, passionate scientist who will dedicate this challenging project.


  • Investigation of the molecular mechanism of IL-27 and anti-viral miRNA-mediated anti-virus effect, ROS and autophagy induction in multiple cell types.
  • Run multiple instrument: confocal microscope (Zeiss), fluorescence microscopy (Zeiss, Nikon), AMINIS;FlowSight imaging flow cytometry, Sanger DNA sequence, Nexseq2000, single-cell RNA-seq, Singel-cell proteomics, Quanterix ELISA system, RNA scope.
  • Analysis of Big Data using piplines with staff in the bioinformatic section.
  • Publishing  paper(s) and presenting the findings in the international or domestic scientific conference(s) as the first author.



To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

  • Possession of a Ph.D. or M.D./Ph.D. from an accredited college or university according to the Council for Higher Education Accreditation (CHEA) . (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for U.S. equivalency.
  • No Experience in virus study required with the degree.
  • Publication of the first author paper(s).
  • Ability to obtain and maintain a security clearance.


Candidates with these desired skills will be given preferential consideration:  

  • Handling of RNA and RT-PCR
  • Construction of plasmid using the in-fusion cloning technology
  • Tissue culture (primary cells and cell lines) for long period.
  • Transfection of DNA, siRNA or shRNA and Handling of lentiviruses
  • Western blotting and ELISA
  • Statistical analysis skills


  • This position is subject to working with potential for exposing to infectious materials, requiring medical clearance and immunizations under SOP.
  • This position is subject to working with or have potential for exposure to infectious
    material, requiring medical clearance and immunizations.

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)



A rewarding career with global impact

Whether you’re an expert in your field or just starting out, we have a career opportunity for you. We’re always looking for people to join us in fulfilling the mission of the Frederick National Laboratory: discovery, innovation, and success in the biomedical sciences.

Our team of 2,400+ scientists, technicians, administrators, and support staff work at the forefront of basic, translational, and preclinical science, with a focus on cancer, AIDS, and other infectious diseases.

We collaborate with colleagues across the National Cancer Institute, National Institutes of Allergy and Infectious Diseases, and others throughout the National Institutes of Health. We also engage with extramural investigators in academia, government and industry.

Your path to joining our team begins with the desire to work for the only national laboratory dedicated to biomedical research. Our employees share a common desire to help make a difference in cancer research and public health concerns. As you search for a career that fits your education, skills, and abilities, explore the core values that guide us and emphasize work-life balance.

Discover why joining the Frederick National Laboratory team could be the most important career step you take



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