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Scientist, Discovery Biology

Theseus Pharmaceuticals
Cambridge, MA
Start date
Feb 23, 2023

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Science/R&D, Biology, Biotechnology
Required Education
Position Type
Full time

Job Details

Theseus Pharmaceuticals is passionately committed to improving the lives of cancer patients by working to outsmart cancer resistance. Led by a team of targeted oncology pioneers with a proven track record developing and commercializing cancer therapeutics, we are developing the next generation of tyrosine kinase inhibitors (TKIs): “pan-variant” targeted therapies that address all known drug-resistant mutations. We believe a pan-variant approach is the only way to address cancer resistance. Our lead program, THE-630, is a pan-variant KIT inhibitor for patients with advanced gastrointestinal stromal tumors (GIST), whose cancer has developed resistance to earlier lines of kinase inhibitor therapy. We are also developing a fourth-generation, selective epidermal growth factor receptor (EGFR) inhibitor to address C797S-mediated resistance to first- or later-line osimertinib treatment in patients with non-small cell lung cancer (NSCLC).

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Role: Scientist, Discovery Biology

We are looking for a talented and passionate Discovery Biologist who is excited to leverage the latest advances in biology, chemistry, and computation to help us discover promising new cancer drugs. The successful candidate will be responsible for target validation, assay development, and analysis of in vitro and cellular data, and will be a key member of the team that discovers our next clinical candidate(s). You will carry out these responsibilities overseeing a team of external scientists across multiple CROs.

Who are we looking for?

  • A driven professional who knows how to work and contribute to an ever-changing working environment
  • A willingness to learn new things, adapt to new ways and go with the flow

What are we looking for?

  • You are a resourceful self-starter, take a hands on approach, and are a team player with a strong results-based orientation
  • You can develop trusting relationships to gain support and achieve results at all levels of the organization

What are we offering?

  • Membership within a growing, CARING, and collegial organization
  • Being part of passionate, involved, and cutting-edge Discovery Team
  • Exposure to pioneering science and the discovery of drugs to help treat patients with cancer

What you will do:

  • Partner with leadership to plan and prioritize target selection, biology strategy and workflows
  • Select, design, and validate an extensive array of predictive in vitro and cellular assays and manage their execution by direct oversight of external CROs
  • Provide sophisticated data analysis and interpretation to help guide drug discovery and evaluation of meaningful go/no-go decisions
  • Provide guidance in identifying and validating biomarkers and indication selection for clinical development
  • Work closely and collaboratively with a talented group of internal scientists across Biology (including Translational and Structural), Pharmacology, Chemistry (including Computational) and DMPK functions
  • Leverage a network of external scientific advisors and consultants to execute research activities

What you will bring:

  • Ph.D. and post-doctoral fellowship in a relevant field of biomedical research; industry experience is a plus
  • Strong background in oncology/cancer research, with a thorough understanding of signaling pathways implicated in disease and the mechanism of action of targeted therapies
  • A very high level of motivation and a proven record of accomplishment (eg, a strong publication record)
  • Experience performing and analyzing a broad array of molecular and cell biology studies
  • Track-record of adopting highly innovative approaches to answering complex biological questions
  • Excellent interpersonal skills, leadership abilities, and oral and written communication

Our values:

Transparency: We work with honesty, openness, and integrity.

Community: We collaborate and thrive together.

Patient-Focused: We are committed to finding new medicines for patients.

Resolve: We never give up on our mission.

When You Join Theseus Pharmaceuticals You Will Have:

  • Location reachable by public transportation (Red Line)
  • Customized and competitive health coverage, including medical offered through BCBS (HMO/PPO), dental, and vision
  • Health Savings Account for medical expenses
  • Eligible from the first day for 401K with 100% match of the first 5%
  • A robust package of Theseus-paid insurance coverage, including life insurance, short-term and long-term disability
  • Unlimited time off and 11 Holidays
  • Winter Break: Theseus is closed for a Winter Break between Christmas and New Year

Location: Cambridge (Kendall Square), MA

Candidates should be aware that Theseus Pharmaceuticals requires all employees to be fully vaccinated against COVID-19. Newly hired employees must be vaccinated prior to their employment start date. Theseus is an equal opportunity employer and will provide reasonable accommodation to those unable to be vaccinated where it is not an undue hardship to the company to do so as provided under federal, state, and local law.

Theseus Pharmaceuticals is an equal employment opportunity employer and does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, disability, genetic information, veteran status, military status, application for military service or any other class protected by state or federal law.

TO ALL AGENCIES: Please, no phone calls or emails to any employee of Theseus about our openings. All resumes submitted by search firms/employment agencies to any employee at Theseus via email, the internet or in any form and/or method will be deemed the sole property of Theseus unless such search firms/employment agencies were engaged by Theseus for this position and a valid agreement with Theseus is in place. In the event a candidate who was submitted outside of the Theseus agency engagement process is hired, no fee or payment of any kind will be paid.


Theseus is a clinical-stage biopharmaceutical company focused on improving the lives of cancer patients through the discovery, development and commercialization of transformative targeted therapies. Theseus is working to outsmart cancer resistance by developing pan-variant tyrosine kinase inhibitors (TKIs) to target all known classes of cancer-causing and resistance mutations that lead to variants in a particular protein in a given type of cancer. Theseus' lead product candidate, THE-630, is a pan-variant KIT inhibitor for the treatment of patients with advanced gastrointestinal stromal tumors (GIST), whose cancer has developed resistance to earlier lines of kinase inhibitor therapy. Theseus is also developing a fourth-generation, selective epidermal growth factor receptor (EGFR) inhibitor for C797S-mediated resistance to first- or later-line osimertinib treatment in patients with non-small cell lung cancer (NSCLC).

Public: THRX

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