Computational Biologist

Job Family:

Travel Required:

Clearance Required:

What You Will Do:

• Operate genome assembly tools, annotation algorithms, genome alignment algorithms (ELAND, BOWTIE, MAQ) on genomic data sets generated by ultra-high throughput sequencing technology (Illumina Solexa Genome Analyzer, Applied Biosystem SOLID, or Roche 454) for de novo transcriptome assembly, ribosome profiling, RNA immunoprecipitation (CLIP-seq or PAR-CLIP), methylation, V(D)J rearrangement, single nucleotide polymorphism, copy number variation, alternative splicing, non-coding RNA, gene expression and chromatin immunoprecipitation (ChIP-seq) analyses.
• Program, operate, and transfer data in UNIX, Linux, Microsoft Windows, and Macintosh OS X systems.
• Write computer code using the scripting languages C/C++, Perl or Python, MATLAB, as well as a statistical language such as R, and work with relational databases and SQL.
• Operate and customize UCSC genome browser mirror for visualizing data sets and genome annotations.
• Develop an integrated computing environment supporting Apple, Microsoft, and UNIX/Linux operating systems using PHP, MySQL, HTML, and XML.
• Perform work on collaborative sequencing projects; other computational needs include but are not limited to Pearson correlation analysis, linear regression, principal component and routine microarray analyses.
• Collaborate with scientists, while seeking to understand their current and potential bioinformatics needs; identify opportunities to apply existing capabilities and optimize operations.
• Assist in the writing, figure generation, publication of manuscripts, and archiving datasets in public/private repositories.
• Reanalyze and integrate data available from collaborators or public repositories.
• Participate in initiatives to improve the efficiency and effectiveness of operations.
• Interface and communicate effectively with IT personnel to troubleshoot problems, improve standard operations, develop and expand computing resources.
• Operate and communicate effectively in a group, team-oriented working environment. Work with and support others in a collegial, open, respectful, and interactive working manner.
• Provide leadership and act as a role model and mentor where appropriate or when needed.
• Demonstrate excellent verbal and written communication skills and maintain excellent laboratory notebooks with sufficient details for reproducing results.
• Maintain accurate sample tracking and data management; familiarity with Laboratory Information Management Systems (LIMS) would be an asset.
• Perform problem solving, call technical support to fix problems, initiate service calls or repairs, and interact with field service engineers and field application specialists for repair and optimization of computational technologies.
• Stay current with regards to latest protocols, applications, scientific methodology, sample handling and processing relevant to next generation DNA sequencing.
• Perform additional duties as assigned.

What You Will Need:

• Advanced degree in mathematics, physics, computer science, bioinformatics, computational biology or software engineering.
• Minimum two (2) years bioinformatics-related experience.
• Have working knowledge of the Illumina Genome Analyzer IIx, HiSeq 2000, Cluster Station and cBot.
• Have working knowledge of methods associated with Illumina sequencing required for analyses of resulting data.
• Willing to learn principles of molecular biology, genetics, systems biology, immunology.
• Demonstrated analytical and programming skills being essential.
• The successful candidate should have the ability to work independently, multi-task, be goal-oriented, and communicate effectively.
• Experience with dynamic web application development using HTML, XML, PHP, and MySQL in a Linux/UNIX environment.
• Experience in programming using Perl, Python and R.
• Able to master new software rapidly and to instruct others in their use.
• Experience with the operation and maintenance of computers with Mac OS X, Linux, Unix, and Microsoft Windows operating systems.
• Competency with statistics and quantitative analyses.
• Attention to detail, strong organizational and troubleshooting abilities, strong written and oral communication skills.
• Must have a high degree of understanding of the theories, principles, practices and methods in the application of ultra-high throughput DNA sequencing as well as related areas such as Affymetrix/Agilent microarray technologies and extensive familiarity with relevant scientific literature.
• Skill to determine the specific experimental data needed and the best approaches and methods to obtain and analyze these data.
• Skill to modify existing analysis software and to develop new approaches to solve problems; to accommodate unusual or unprecedented analytical requirements during the conduct of research projects.
• Ability to formulate sound conclusions, prepare reports summarizing research results, analytical methods performed, interpretation of results, and identify critical scientific questions that require further study; must be able to differentiate when analysis succeeded or failed.
• Practical knowledge of and skill in computerized data analysis, database management, and computer programming in order to conduct an evaluation of experimental data.
• Take initiative to improve the efficiency and effectiveness of daily operations to develop best practices and standard operating procedures for analyzing data in a timely and sound manner.
• Must display flexibility and personal initiative to explore new strategies to solve problems and accomplish project goals.
• Work with and interact with post-baccalaureate IRTAs, graduate students, post-doctoral researchers, principal investigators, lab chiefs, and technicians.

What Would Be Nice To Have:

What We Offer:

Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

Benefits include:

• Medical, Rx, Dental & Vision Insurance

• Personal and Family Sick Time & Company Paid Holidays

• Parental Leave

• 401(k) Retirement Plan

• Group Term Life and Travel Assistance

• Voluntary Life and AD&D Insurance

• Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts

• Transit and Parking Commuter Benefits

• Short-Term & Long-Term Disability

• Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities

• Employee Referral Program

• Corporate Sponsored Events & Community Outreach

• Care.com annual membership

• Employee Assistance Program

• Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)

• Position may be eligible for a discretionary variable incentive bonus

About Guidehouse
Guidehouse is an Equal Employment Opportunity / Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to race, color, national origin, ancestry, citizenship status, military status, protected veteran status, religion, creed, physical or mental disability, medical condition, marital status, sex, sexual orientation, gender, gender identity or expression, age, genetic information, or any other basis protected by law, ordinance, or regulation.

Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.

If you have visited our website for information about employment opportunities, or to apply for a position, and you require an accommodation, please contact Guidehouse Recruiting at 1-571-633-1711 or via email at RecruitingAccommodation@guidehouse.com. All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodation.

Guidehouse does not accept unsolicited resumes through or from search firms or staffing agencies. All unsolicited resumes will be considered the property of Guidehouse and Guidehouse will not be obligated to pay a placement fee.