Senior Manager, Infectious Disease Research

The Role:
Moderna is seeking an experienced x-ray crystallography Senior Manager to function in a fast-paced and collaborative environment. This position is based at the Moderna Norwood site reporting to Associate Director leading the Structural Biology Team. The Sr. Manager will help develop and implement structural characterization workflow to support the advancement of Modernas mRNA technology platform. S/he/they should be able to apply various structural/biophysical/biochemical techniques and work in a highly collaborative, dynamic, and interdisciplinary environment. The successful candidate is expected to have hands-on experience including crystallography hardware operation and maintenance, sample management (crystal freezing and shipment), data acquisition at synchrotrons, data storage and processing. In addition, the Sr. Manager will work closely and collaboratively with the associated cryo-EM facility to maximize the output of the collective structural biology efforts in Moderna.

Heres What Youll Do:

• Develop and implement x-ray crystallography workflow for protein and nucleic acid samples

• Carry out protein crystallization trials and optimize logistics of crystal management for synchrotron data collection

• Keep up to date with x-ray crystallography technologies

• Manage agreements with synchrotrons and contract research organizations

• Support compliance with safety and lab procedures; partner with EH&S and lab users to support new lab safety initiatives

• Working closely with service engineers to achieve high performance of crystallography instruments while minimizing downtime

• Collaborate with IT department to upkeep data management

• General laboratory assistance, including x-ray crystallography and biochemistry lab equipment maintenance. Source, stock and inventory of crystallography supplies.

• Organize space to meet short/long term objectives

• Careful record keeping, data organization and presentation

• Provide cross support to the associated cryo-EM facility

• Enable structure-based designs and validation for relevant antigens of diverse infectious diseases by solving structures of antigens alone or in complex with antibodies

• Process crystallography data and refine model coordinates utilizing state-of-art software including HKL2000/3000, CCP4 and Phenix packages, Coot, PyMol, Chimera and others in an Amazon Cloud environment

Heres What Youll Bring to the Table:

• A PhD degree in physical sciences with at least 2-3 years of hands-on experience of x-ray crystallography; industry experience desirable but not a must; laboratory oversight experience a plus. Alternatively, candidates with a MS degree in physical sciences with more than 7-8 years of relevant crystallography experience will be considered

• Hands on experience with crystallization instruments, including crystallization robot operation, crystal growth monitoring using automated camera system, freezing crystals for shipment, data acquisition at synchrotrons, and data processing using sophisticated software packages.

• Experience with negative-stain electron microscope and/or cryo-electron microscopy is a plus

• Excellent skills and ability to work and communicate efficiently in a multicultural highly dynamic and matrixed environment

Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:

• Highly competitive and inclusive medical, dental and vision coverage options
• Flexible Spending Accounts for medical expenses and dependent care expenses
• Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities
• Family care benefits, including subsidized back-up care options and on-demand tutoring
• Free premium access to fitness, nutrition, and mindfulness classes
• Exclusive preferred pricing on Peloton fitness equipment
• Adoption and family-planning benefits
• Dedicated care coordination support for our LGBTQ+ community
• Generous paid time off, including:
  Vacation, sick time and holidays
  Volunteer time to participate within your community
  Discretionary year-end shutdown
  Paid sabbatical after 5 years; every 3 years thereafter
• Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents
• 401k match and Financial Planning tools
• Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
• Complimentary concierge service including home services research, travel booking, and entertainment requests
• Free parking or subsidized commuter passes
• Location-specific perks and extras!

Candidates should be aware that Moderna currently maintains a policy requiring all US-based employees to be fully vaccinated against COVID-19 and receive a booster shot once eligible. Newly hired employees must be vaccinated and boosted prior to their employment start date. Moderna is an equal opportunity employer and will provide a reasonable accommodation to those unable to be vaccinated or receive a booster where it is not an undue hardship to the company to do so as provided under federal, state, and local law.

About Moderna

In over 10 years since its inception, Moderna has transformed from a research-stage company advancing programs in the field of messenger RNA (mRNA), to an enterprise with a diverse clinical portfolio of vaccines and therapeutics across seven modalities, a broad intellectual property portfolio in areas including mRNA and lipid nanoparticle formulation, and an integrated manufacturing plant that allows for rapid clinical and commercial production at scale. Moderna maintains alliances with a broad range of domestic and overseas government and commercial collaborators, which has allowed for the pursuit of both groundbreaking science and rapid scaling of manufacturing. Most recently, Moderna's capabilities have come together to allow the authorized use and approval of one of the earliest and most effective vaccines against the COVID-19 pandemic.

Moderna's mRNA platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, and has allowed the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases, cardiovascular diseases and autoimmune diseases. Moderna has been named a top biopharmaceutical employer by Science for the past seven years. To learn more, visit www.modernatx.com.

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a persons race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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