Protein Scientist (Expression)
- Employer
- BigHat Biosciences
- Location
- San Mateo, CA
- Start date
- Jan 18, 2023
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- Discipline
- Science/R&D, Bioengineering, Biotechnology, Molecular Biology
- Required Education
- Doctorate/PHD/MD
- Position Type
- Full time
- Hotbed
- Biotech Bay
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The Role: BigHat Biosciences is looking for a motivated and energetic Protein Scientist with a strong background in cell-based protein expression to further advance BigHat’s platform for ML-driven antibody discovery and engineering.
*At BigHat we believe in titles that are commensurate with skill set, relative organizational impact, and value contribution; more experienced candidates are encouraged to apply, with the understanding that responsibilities and title would adjust as appropriate.
Key Responsibilities
Preferred Qualifications
*At BigHat we believe in titles that are commensurate with skill set, relative organizational impact, and value contribution; more experienced candidates are encouraged to apply, with the understanding that responsibilities and title would adjust as appropriate.
Key Responsibilities
- Onboard protein expression using transient transfections in Expi293 and/or ExpiCHO cells at 5 mL to 1 L scales
- Design, develop, and execute production workflows for molecule design, plasmid construction, expression, titering, and harvest
- Expression of antigens and various antibody formats, including fragments, IgGs, novel fusion proteins, and bi- and multi-specifics
- Evaluation and incorporation of emerging technologies for higher expression, increased speed, and/or decreased COGs
- Work collaboratively with cross-functional internal teams and external service providers to ensure timely completion of deliverables
Preferred Qualifications
- Ph.D and at least one (1) year of hands-on working experience related to protein expression, preferably with antibody molecules using Expi293 or ExpiCHO cells
- A strong molecular biology background for developing efficient cloning workflows
- Prior innovation in mammalian expression for increasing yield, speed, or throughput
- Appetite for learning and using new tools and technologies to support core responsibilities and cross-functional communication
- A strong can-do mentality and desire to thrive in a dynamic start-up environment
- Nice-to-haves include experience in protein purification, analytics, or automation
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