The Gladstone Institutes is seeking a talented and motivated scientist to direct the Gladstone Metabolomics Platform. The successful candidate will work closely and collaboratively with Gladstone scientists on a range of research projects employing targeted and untargeted metabolomics and lipidomics, as well as introducing cutting edge analytical and mass-spec techniques to propel science at the Gladstone. The successful candidate will be responsible for training and interacting with individual lab members. They will be actively engaged in experimental design, analysis, manuscript preparation and grant writing. They will have access to resources to set-up and maintain a state-of-the-art metabolomics platform (with full-time access to a Thermo Exploris 240). They will be interacting closely with the Gladstone Mass Spec Center.
Serve as the lead on multiple projects using metabolomics and lipidomics to solve exciting problems related to human health, metabolism and physiology
Manage and improve metabolomics and lipidomics platforms and associated data analysis pipelines
Ensure rigorous analysis and high-quality data acquisition to drive research projects to completion
Develop recommendations about instrumentation purchase/maintenance, data infrastructure, project goals etc.
PhD in Biochemistry, Analytical Chemistry or related field with experience in metabolomics (and ideally, lipidomics)
Experience in metabolomics method development and mass spectrometry data interpretation (e.g. identification and follow-up of unknown peaks)
Familiarity with high-resolution mass spec machines and techniques (e.g. Thermo platform)
Ability to develop custom metabolite extraction methods, chromatography conditions, etc. for relative and absolute quantification of metabolites
Expertise preparing tissue, cell, plasma or spent media samples for metabolomics experiments to ensure reproducibility and accurate representation of cellular metabolism (metabolism quenching, redox-specific preparations, homogenization, cell lysis, etc).
Expertise in multivariate statistical data analysis that includes understanding of statistical error (FDR, power analysis etc), and practical application areas and limitations of common statistical and visualization methods, some experience with R or Python is desired.
Experience and desire to develop and teach research staff in best practices
Experience working in large teams and communicating with people who have little or no knowledge of mass spectrometry and metabolomics.
- Title and salary will be commensurate with education and experience.
- Gladstone is an equal opportunity employer.