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Senior Scientist, Downstream Process Development, Gene Therapy

Waltham, MA
Start date
Nov 29, 2022

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Engineering, Science/R&D, Biotechnology, Biotherapeutics
Required Education
Bachelors Degree
Position Type
Full time
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Job Details

Resilience is seeking a talented Senior Scientist in downstream process development (PD) for the Gene Therapy Franchise. The downstream PD team operates with the mission to develop and transfer robust, scalable, cost effective viral vector purification and formulation processes for Resilience's partners and drive development and implementation of innovative internal technology platforms. This scientist will work collaboratively with other members of the PD and analytical development teams to advance these objectives.

Job Responsibilities

  • Design and perform world-class downstream technology protocols from bioreactor recovery, affinity-column purification, impurity removal, particle enrichment strategies, ultrafiltration and diafiltration (UF/DF), and sterile filtration
  • Advance current methods and develop new methods to purify viral vectors, leaving no stone unturned
  • Collaborate with suppliers and vendors on design, procurement and testing of PD equipment
  • Ensure documentation and data management best practices are followed, reviewing documentation as needed
  • Support collaborations with partners, clients, technology developers, and suppliers

Required Qualifications

  • Bachelor's or Master's degree with 7+ years of relevant experience in downstream viral vector process development, or PhD degree with 4+ years of relevant industry experience
  • Background in the development of column purification, UF/DF, sterile filtration, product recovery strategies
  • Understanding of downstream process development, scale up and technology transfer
  • Excellent written and verbal communication skills

Preferred Experience

  • Experience applying scientific principles and concepts to potential innovative platforms and disruptive technologies
  • Experience with process characterization and Design of Experiments (DOE)
  • Understanding of early and late-stage process development

Other Ideal Personal Characteristics

  • Embodies the Resilience phenotypes of grit, rigor, service, EQ+IQ, builder mentality, velocity, and ownership
  • Intellectually curious, flexible, able to contribute at a very high level, as well as possessing a hands-on manner, when necessary
  • Collaborative style, with an ability to build consensus among both internal and external stakeholders



Resilience is a technology-focused biomanufacturing company dedicated to broadening access to complex medicines. Founded in 2020, the company is building a sustainable network of high-tech, end-to-end manufacturing solutions to ensure the treatments of today and tomorrow can be made quickly, safely, and at scale. Resilience seeks to free its partners to focus on the discoveries that improve patients’ lives by continuously advancing the science of biopharmaceutical manufacturing and development. For more information, visit and follow us on Twitter @IncResilience 

Find Us
9310 Athena Circles
La Jolla
United States
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