Associate Scientist I, Pharmacology

DESCRIPTION

We are seeking a highly motivated individual to join the In Vivo Pharmacology group. The Associate Scientist I will conduct tumor efficacy and PK/PD studies, develop novel preclinical models and provide pharmacology support to innovative cancer drug development. The position will report to Senior Scientist and work collaboratively in a project team setting with biology, medicinal chemistry and DMPK scientists, providing in vivo proof-of-principle for target discovery and validation, formulating and executing efficient in vivo structure activity relationship strategy and advancing oncology programs to clinical development.

General Position Summary/Purpose:

Provide preclinical Pharmacology support to Abbvie drug discovery and development projects in oncology. Implement novel experimental approaches to tumor model development, efficacy/PK/PD/ in vivo mechanism-of-action investigation, target discovery and validation, disease mechanisms, resistance biology, and tumor microenvironment interaction in support of drug discovery and development. Investigate, develop, validate or optimize existing and new methods/models to solve project related scientific problems. Generate efficacy and PD data to support preclinical development of drug candidates and regulatory submissions. Develop productive collaborations and communications with other groups across scientific disciplines.

• Conduct tumor efficacy, imaging and PD studies to support in vivo POC, SAR and IND submission.
• Report/present analyses of in vivo studies.
• Understand and adhere to IACUC protocols regarding animal welfare and handling.
• Cell culture, sorting and genetic manipulation of cells to support efficacy studies and tumor model development.
• Conduct ex vivo assays such as FACS, MSD, WES and Luminex to understand MOA of in vivo studies.
• Improve existing Pharmacology workflows and data visualization tools.
• Commitment to scientific rigor, high data quality and careful documentation.
• Self-motivated, possess strong problem solving and organizational skills.
• Ability to manage multiple responsibilities, adapt to changing priorities and meet deadlines in a fast-paced environment.
• Excellent written and verbal communication skills.
• Flexibility and motivation to learn techniques and accomplish goals outside those stated above.

• BS/MS in pharmacology, cancer biology, or related field with 0-2 years of drug development experience in a pharmaceutical or biotech industry setting.
• A strong background in pharmacology and cancer biology.
• Proficient hands-on experience with tissue culture, tumor implantation, mouse dosing, bleeding and tissue harvesting.
• Technical experience in flow cytometry, primary cell culture, tissue processing, as well as other standard molecular and cellular biology assays (MSD, ELISA, Wes, etc.) is preferred
• Strong teamwork spirit, good listener, eager to learn new skills
• Must be proactive and able to work effectively on multiple experiments in a fast-paced, dynamic environment.
• Strong written and verbal communication skills, good record keeping and organization skills, attention to details
• Demonstrated ability to work independently and collaboratively to execute experiments

At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity and affirmative action employer, we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic. If you would like to view a copy of the company’s affirmative action plan or policy statement, please email CorpJat_ABV@abbvie.com.