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Senior Research Associate, Cell Therapy Drug Product Development

Employer
Sana Biotechnology
Location
South San Francisco, CA
Start date
Nov 28, 2022

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Job Details

 

About the role

Sana Biotechnology is growing, and we are hiring new team members who believe in the potential of engineered cells as medicines, who want to challenge status quo, and who lead with the desire to work on novel ideas. As a Senior Research Associate, Cell Therapy Drug Product (DP) Development, you will report to Director, Cryopreservation to perform experiments to help develop formulation, fill and finish, and cryopreservation and provide onsite support at the manufacturing facility for our pipeline cell therapy drug products. You will be also expected to collaborate with multiple teams including Process Development, Analytical Development and Manufacturing.

What you’ll do

  • Develop small- and large-scale fill/finish processes and conduct in-use compatibility study on allogeneic cell therapy products
  • Perform DP process-enabling studies including formulation development, cryopreservation, and thawing
  • Conduct cell health and viability assessment, including cytotoxicity, apoptosis, and proliferation assays, and interpret flow cytometry data
  • Provide onsite support at the GMP manufacturing facility (e.g., CDMO), train operators, and oversee process execution
  • Perform data analysis and interpretation and draw main conclusions to present at group and cross-functional team meetings
  • Make detailed observations and document experimental methods in an electronic laboratory notebook
  • Draft technical documents including reports, operating procedures, and master batch records

What we’re looking for

  • in Biology, Chemical or Biomedical Engineering, or related field plus 4 years or MSc. plus 1+ years of work experience
  • Multiple years of progressive, industrial experience in cell therapy DP process development and manufacturing, including formulation, filling, and cryopreservation
  • Well versed with cGMP requirements and working in a regulated environment
  • You are a team player with experience working with cross-functional teams through effective communications and coordination.
  • You are self-motivated with strong curiosity and creative-thinking skill, demonstrated scientific rigor, and a continuous drive to learn new skills and techniques.

What will separate you from the crowd

  • Prior experience working on a clinical or commercial cell therapy manufacturing process
  • Deep knowledge of cryobiology, specialized in cryopreservation methods and mechanisms of cryopreservation-induced cell injuries
  • Extensive hands-on experience working on formulation development, manual or automated filling instrument, and controlled rate freezer
  • Experience with analytical methods including cell counts and viability using automated cell counters and flow cytometry
  • Knowledge of R, Python, JMP, Benchling and FlowJo software
  • Experience optimizing process parameters using Design of Experiments (DoE)

What you should know

  • Handling of human blood products
  • Some weekend work required
  • Work in a laboratory environment approximately 75% of the time
  • 10% travel anticipated
  • Working safely in person on a predictable and regular in-person basis is an essential job function for this position, and the Company requires that all individuals working in-person be fully vaccinated against COVID-19, including receipt of a vaccine booster shot if recommended by the CDC

How we work together

  • Lead from every seat – we seek to understand, act with honesty, and engage in the crucial conversations
  • Thrive as a team – we hire amazing people, are intensely curious, and cultivate inclusion and personal connectivity
  • Make it happen – we value vigorous debate, alignment around our decisions, and resilient execution

Get to know us

At Sana, we believe that a diverse workforce strengthens us as a company and helps us to achieve our mission to meaningfully change the outcome of many human diseases. This belief is a pillar of our business and is critical to our success. Our goal is that Sana is the place for talented people to bring their authentic selves to work, to have a great career and to deeply, positively impact patients.

Core to our values, we believe there is nothing more important than the health and wellness of you and your family. For benefit eligible employees, we cover 100% of the cost for employee health coverage and offer generous time-off, parental leave, short- and long-term disability, employer paid basic life insurance,  additional voluntary life insurance protection, financial wellness programs including financial planning resources, a 401(k) Plan with an immediately vested employer match, Tuition Reimbursement and Student Loan Repayment, Employee Stock Purchase Plan, commuter subsidy and a variety of wellness offerings to support each person individually.

We are committed to providing a workplace free of discrimination and harassment based on race, color, religion, age, gender, national origin, ancestry, physical or mental or sensory disability (including the use of a trained guide dog or service animal by a person with a disability), genetic information, actual or perceived HIV or Hepatitis C infection, medical condition (cancer or a record or history of cancer and genetic characteristics), marital status, sexual orientation, sexual preference, pregnancy (including childbirth and related medical conditions), disability, veteran status, political ideology, social class (including caste/caste identity), taking or requesting statutorily protected leave, status as a victim of domestic violence, sexual assault or stalking, or any other basis prohibited by applicable law.

To perform this job successfully, you must be able to perform each job responsibility satisfactorily. The job description listed above is representative of the knowledge, skills, and/or abilities required for this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the functions described above.

Company

Sana Biotechnology, Inc. is focused on creating and delivering engineered cells as medicines for patients. We share a vision of repairing and controlling genes, replacing missing or damaged cells, and making our therapies broadly available to patients. We are a team of 320 plus scientists, engineers, clinicians and biotechnology veterans creating an enduring company that makes meaningful medicines and changes how we approach treating disease. Sana has operations in Seattle, Cambridge, and South San Francisco.

Find Us
Website
Mini-site
Sana Biotechnology
Location
188 East Blaine Street, Suite 400
Seattle, WA 98102
US
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