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Sr. Research Associate, In Vivo Pharmacology, Oncology Research

Employer
Moderna, Inc.
Location
Cambridge, MA
Start date
Nov 26, 2022

View more

Discipline
Regulatory, Science/R&D, Oncology, Pharmacology
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Genetown, Best Places to Work
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Job Details

The Role:

Moderna Oncology Research is looking for a talented and motivated in vivo pharmacologist to focus on validating new mRNA-based therapies in cancer. The successful candidate will primarily work with in vivo tumor models and be responsible for validating the in vivo pharmacology and therapeutic utility of novel mRNA therapeutics. Applicants should be great team members and have a track record of independent research accomplishments. The ability to effectively communicate with internal team members is required.

Heres What Youll Do:

  • Perform and/or take lead on routine in vivo pharmacology studies (including tumor growth kinetics, tolerability, anti-tumor efficacy, formulations screens, in vivo expression, biodistribution, and pharmacokinetic and pharmacodynamic studies)

  • Organize and perform all tasks associated with routine in vivo pharmacology studies (including tissue culture, preparation and identification of experimental animals, implantation of cancer cells/materials, preparation of test articles, dose administration and necropsy and tissue collection for downstream processing).

  • Develop new mouse models of cancer to test various messenger RNA therapeutics

  • Study data collection with StudyLog and analysis with GraphPad Prism software

  • Matrix with internal teams on initial testing of mRNAs

  • Adhere to all Moderna IACUC protocols, policies and guidelines ensuring that the highest standard of animal welfare is maintained in all studies involving experimental animals

  • Deliver reproducible results under aggressive timelines

  • Independently organize experiments

  • Analyze, interpret and present data

  • Faithfully document scientific work; contribute to reports and presentations

Heres What Youll Bring to the Table:

Minimal Qualifications:

  • B.S. in a biological science with 2-5 years relevant full-time hands on in vivo experience; M.S. with >1 years relevant full-time hands on in vivo experience

  • Solid background in tumor biology and pharmacology

  • Experience in the following:

    • Pharmacological agent administration via IV, IP, and SC dosing routes

    • Implantation of cancer cell lines and tumor-derived material in SC space

    • Collection of serum/plasma/whole blood, tissues, primary tumor material and metastases

    • Mouse anesthesia/analgesia

    • Whole animal and ex vivo imaging

  • Effective oral and written communication skills

  • Readily adapt to change and new projects

Preferred Qualifications:

  • Expertise in the following:

  • Tissue/cell culture expertise:

    • Cell passaging, archiving, harvesting for implant

    • Expertise in performing anti-tumor efficacy and PK/PD studies across multiple syngeneic tumor models

    • Bioluminescent/fluorescence imaging using an IVIS Spectrum In Vivo Imaging System and Living Image software

    • Advanced necropsy and tissue collection in rodents

Competencies:

  • Technical expertise

  • Attention to detail

  • Results oriented

  • Readily adaptable to change and new challenges

  • Ability to work individually or as a member of a team

  • Strong work ethic

  • Scientific rigor

  • Highly effective oral and written communication skills

Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:

  • Highly competitive and inclusive medical, dental and vision coverage options
  • Flexible Spending Accounts for medical expenses and dependent care expenses
  • Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities
  • Family care benefits, including subsidized back-up care options and on-demand tutoring
  • Free premium access to fitness, nutrition, and mindfulness classes
  • Exclusive preferred pricing on Peloton fitness equipment
  • Adoption and family-planning benefits
  • Dedicated care coordination support for our LGBTQ+ community
  • Generous paid time off, including:
    Vacation, sick time and holidays
    Volunteer time to participate within your community
    Discretionary winter shut down
    Paid sabbatical after 5 years; every 3 years thereafter
  • Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents
  • 401k match and Financial Planning tools
  • Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
  • Complimentary concierge service including home services research, travel booking, and entertainment requests
  • Free parking or subsidized commuter passes
  • Location-specific perks and extras!

Candidates should be aware that Moderna currently maintains a policy requiring all US-based employees to be fully vaccinated against COVID-19 and receive a booster shot once eligible. Newly hired employees must be vaccinated and boosted prior to their employment start date. Moderna is an equal opportunity employer and will provide a reasonable accommodation to those unable to be vaccinated or receive a booster where it is not an undue hardship to the company to do so as provided under federal, state, and local law.

About Moderna

In over 10 years since its inception, Moderna has transformed from a research-stage company advancing programs in the field of messenger RNA (mRNA), to an enterprise with a diverse clinical portfolio of vaccines and therapeutics across seven modalities, a broad intellectual property portfolio in areas including mRNA and lipid nanoparticle formulation, and an integrated manufacturing plant that allows for rapid clinical and commercial production at scale. Moderna maintains alliances with a broad range of domestic and overseas government and commercial collaborators, which has allowed for the pursuit of both groundbreaking science and rapid scaling of manufacturing. Most recently, Moderna's capabilities have come together to allow the authorized use and approval of one of the earliest and most effective vaccines against the COVID-19 pandemic.

Moderna's mRNA platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, and has allowed the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases, cardiovascular diseases and autoimmune diseases. Moderna has been named a top biopharmaceutical employer by Science for the past seven years. To learn more, visit www.modernatx.com.

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a persons race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

#LI-SP1

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Company

Moderna is advancing messenger RNA (mRNA) science to create a new class of transformative medicines for patients. Moderna’s platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, providing the Company the capability to pursue in parallel a robust pipeline of new development candidates. Moderna is developing therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases and cardiovascular diseases, independently and with strategic collaborators.

mRNA is now a turning point in the history of science, medicine, technology, even humankind itself. With this breakthrough discovery, many of the world’s biggest and most challenging medical problems are no longer a question of “how?” but merely a question of “when?”

Come with us as we pursue the uncharted reaches of possibility and make your mark on the future of medicine.

 

Stock Symbol:

MRNA  

Stock Exchange:

USNASDAQ GS

 

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Find Us
Website
Phone
617-714-6500
Location
200 Technology Square
Cambridge, MA
US
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