Scientist I / II Biochemistry

About AbbVie

AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

AbbVie employees in the Bay Area bring deep scientific expertise and commercial excellence to advance cancer care. Current oncology areas of focus include immuno-oncology, tumor targeting, tumor dependency and precision medicine. With facilities positioned in the heart of the biotechnology industry, we can collaborate with the best and brightest minds in oncology.

DESCRIPTION:

We are seeking a protein purification scientist to be part of a well-integrated discovery team. As a member AbbVie’s Biologics Discovery Sciences group, you will play a key role in the production and characterization of antibody-based molecules and collaborate with Oncology Discovery scientists to deliver differentiated best-in-class biologics. The candidate will be a highly motivated scientist with an established track record in biochemistry, molecular biology, and protein production. The successful candidate will be expected to work with other scientists within BDS, across functions and different therapeutic areas (Virology, Neurosciences, Immunology and Oncology) to discover and develop next generation biologics through interrogation and engineering of protein attributes. This position is based at our brand new state-of-the-art South San Francisco campus.

KEY RESPONSIBILITIES:

• Understand and execute processes for the expression, purification, and characterization of protein biotherapeutics.
• Plan experimental approaches with minor supervisory guidance.  Discuss, troubleshoot, recommend, and modify experimental techniques as needed.
• Develop and perform intact/reduced liquid chromatography-mass spectrometry (LC-MS) methods and analysis.
• Collaborate cross-department to come up with the most effective approach to meet the demands of biologic development
• Champion new technologies to achieve project goals.
• Communicate and actively engage with discovery scientists, collaborators, and outside vendors.

QUALIFICATIONS:

• Scientist I  - BS or MS degree in chemistry, biology, biochemistry, or related technical discipline with 5+ (BS), 2+ (MS) years of relevant experience in academic or biotech/pharmaceutical industry setting
• Scientist II  - BS or MS degree in chemistry, biology, biochemistry, or related technical discipline with 7+ (BS), 5+ (MS) years of relevant experience in academic or biotech/pharmaceutical industry setting
• A proven record of success in the expression, purification, and characterization of mammalian proteins, including antibodies, antibody fragments, and novel protein constructs
• Experience with sterile technique and handling multiple cell lines in support of transient expression platforms (e.g., HEK293 and CHO)
• Experience in the use of various chromatography and purification systems (protein A/G, SEC, mixed-mode with AKTA systems), and analytical instruments (Agilent HPLC, Waters UPLC and LC/MS, SDS-PAGE)
• Demonstrated ability to enhance protein production capabilities through identification of key technology improvements, innovation, and/or problem solving
• Independently perform reduced LC-MS analyses of AbbVie’s biologics to provide sequence verification, post-translational modification profiles, sequence variant levels, and disulfide bond profiles
• Experience working in highly collaborative environment and the ability to work with others to set and meet organizational goals.

At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity and affirmative action employer, we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic. If you would like to view a copy of the company’s affirmative action plan or policy statement, please email CorpJat_ABV@abbvie.com.