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Director, Preclinical Development

BigHat Biosciences
San Mateo, CA
Start date
Nov 21, 2022

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The Role: BigHat Biosciences is seeking an exceptional individual to lead next-generation antibody development for BigHat’s therapeutic programs. 
This role reports directly to the CSO; works closely with other executives and senior leaders; and has broad responsibilities across BigHat for pipeline development.
Key Responsibilities The goals and responsibilities of this position include: 
  • Lead the progression of molecules from lead to therapeutic candidate nomination through PK, PD, and toxicological assessment in relevant animal models
  • Source, evaluate, and develop the key assays for advancing lead molecules, including identification and management of relationships with CROs where appropriate
  • Contribute to designing TPP and other internal program development activities as part of the Therapeutic Programs Team
  • Collaborate across BigHat to ensure our platform capabilities enable the preclinical development of state-of-the-art biologics uniquely possible on BigHat’s platform

About You
  • A dynamic thinker with a 5+ year track record of leading key aspects of development programs at a top-tier drug development company along with a deep understanding of the underlying science (MD or PhD).
  • Experience with all aspects of antibody development starting after target validation and early hit evaluation through all aspects of preclinical development; experience fulfilling requirements of regulatory filings to initial clinical testing is desired but not essential 
  • Able to manage multiple unrelated projects concurrently including relationships with collaborators, partners, or CROs to advance a lead molecule to regulatory submission in a timely manner.
  • A get-it-done mentality; experience operating in lean organizational structures.
  • Superb execution and communication skills 
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