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Protein Scientist (Expression)

BigHat Biosciences
San Mateo, CA
Start date
Nov 19, 2022

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Science/R&D, Bioengineering, Biotechnology, Molecular Biology
Required Education
Position Type
Full time
Biotech Bay
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The Role: BigHat Biosciences is looking for a motivated and energetic Protein Scientist with a strong background in cell-based protein expression to further advance BigHat’s platform for ML-driven antibody discovery and engineering.
*At BigHat we believe in titles that are commensurate with skill set, relative organizational impact, and value contribution; more experienced candidates are encouraged to apply, with the understanding that responsibilities and title would adjust as appropriate. 
Key Responsibilities
  • Onboard protein expression using transient transfections in Expi293 and/or ExpiCHO cells at 5 mL to 1 L scales
  • Design, develop, and execute production workflows for molecule design, plasmid construction, expression, titering, and harvest
  • Expression of antigens and various antibody formats, including fragments, IgGs, novel fusion proteins, and bi- and multi-specifics
  • Evaluation and incorporation of emerging technologies for higher expression, increased speed, and/or decreased COGs 
  • Work collaboratively with cross-functional internal teams and external service providers to ensure timely completion of deliverables

Preferred Qualifications
  • Ph.D and at least one (1) year of hands-on working experience related to protein expression, preferably with antibody molecules using Expi293 or ExpiCHO cells
  • A strong molecular biology background for developing efficient cloning workflows
  • Prior innovation in mammalian expression for increasing yield, speed, or throughput
  • Appetite for learning and using new tools and technologies to support core responsibilities and cross-functional communication 
  • A strong can-do mentality and desire to thrive in a dynamic start-up environment
  • Nice-to-haves include experience in protein purification, analytics, or automation
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