Scientist, New Targets Investigation

We are seeking an innovative Scientist to join our dynamic multidisciplinary group - New Targets Investigation (NTI). Within NTI, we seek to identify, characterize, and validate the function of genes critical to disease onset and progression. Informed by human genetics (Regeneron Genetics Center), NTI harnesses state-of-the-art VelociGene technology to generate genetically modified mouse models, interrogate the mechanistic underpinnings of human disease, and develop targeted therapeutics. We are looking for someone who will support the advancement of targets across multiple indication areas (cardiovascular, oncology, inflammation, metabolism) through the development and characterization in-vitro cell, organoid, and mouse models of disease.

In this role a typical day might include the following:

• Investigate, develop, and validate novel disease relevant mouse models, which may include generation of cell specific targeting strategies, surgical manipulation, and genetic approaches.

• Utilize genetic loss- and gain-of-function approaches for assessing target gene function in cell-based and in vivo models

• Interrogate the interaction of pathways central to angiogenesis and vascular function in mouse tumor models

• Develop in vitro and in vivo assays to interrogate the tumor microenvironment (endothelial / myeloid / lymphoid / stroma)

• Work both independently and collaboratively in a team environment

• Lead collaborative research projects

• Perform data analysis, troubleshoot experiments, and record results in an electronic notebook

• Present findings in team, department, and Regeneron leadership meetings  

This role may be for you if you:

• Have a desire to develop therapeutic modalities to address neovascular disease and tumorigenesis

• Have a strong background in mouse tumor models, angiogenesis, vascular biology

• Have strong communication and presentation skills

• Enjoy participating in exciting cross-functional projects involving multiple teams

To be considered for this role, you must have a PhD in Oncology, Biochemistry / Molecular Biology, Cell Biology, Developmental Biology, or a related field, with 3-5 years post-doctoral experience in mouse tumor biology and angiogenesis. We need someone with a background in mouse tumor and angiogenic models. Experience in and knowledge of the study of angiogenic signaling pathways is strongly preferred. Competency in basic molecular biology and cloning methods is required. You should also have experience in developing primary cell-based and ex-vivo assays. Knowledge and experience in flow cytometry and immunophenotyping would be advantageous.

#LI-Onsite

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.

The salary ranges provided are shown in accordance with U.S. law and apply to U.S. based positions, where the hired candidate will be located in the U.S. If you are outside the U.S, please speak with your recruiter about salaries and benefits in your location.

Salary Range (annually)

$103,600.00 - $169,000.00