Scientist, Cancer Immunotherapy (Solid Tumor)
- Employer
- Fate Therapeutics
- Location
- San Diego, CA
- Start date
- Nov 15, 2022
View more
- Discipline
- Science/R&D, Biotechnology, Immunology, Oncology
- Required Education
- Doctorate/PHD/MD
- Position Type
- Full time
- Hotbed
- Biotech Beach, Best Places to Work
Job Details
Responsibilities
- Leverage T cell biology, tumor biology, tumor microenvironment expertise in collaborative efforts with scientists, associate scientists, and research associates to investigate, develop and implement novel strategies for next-generation CAR-iT cell product.
- Lead, design, coordinate and execute prove-of-concept research with precise data analysis, interpretation, and communication capability and deliver results in a timely manner.
- Present results in a multidisciplinary team environment.
- Differentiate and evaluate CAR iT cells with in vitro assays (including cytokine release/degranulation and short/long-term killing assay and RNA-seq) and in vivo murine models.
- Perform viral vector-based gene modification and generate cell line and primary T cells.
Qualifications
- PhD degree in Immunology, Cancer Cell Biology or related fields with 3+ years of T cell relevant experience. Previous experience with research in biotechnology or pharmaceutical industry is preferred, but not required.
- Proven track record of leading or contributing to projects in immunology, or cancer cell biology.
- In-depth experience with multi-parameter flow cytometry is a must, preferably 8+ color.
- Extensive aseptic technique and mammalian cell culture experience with a minimal of 3 years of hands-on experience is a must.
- Self-motivated, well-organized, positive outlook, willingness to learn and contribute, and a team-oriented attitude is a must.
- Experience with immune cell functional assays and gene editing of T cells by transfection or transduction is a plus.
- Experience with human CAR-T cells is a plus.
- Knowledge on T cell development, T cell signal transduction, or cellular immunotherapy in oncology is a plus.
- Experience with IncuCyte and/or xCELLigence platforms is a plus.
- Knowledge with single-cell RNA-seq analysis and bulk RNA-seq analysis is a plus.
Working Conditions and Physical Requirements
- Will require working with cells and cell lines of human and/or animal origin
- Occasional evening and weekend work will be required.
- 100% on-site work at corporate headquarters in San Diego, CA
The preceding job description indicates the general nature and level of work performed by employees within this classification. Additional and incidental duties related to the primary duties may be required from time to time.
Equal Employment Opportuntiy
Fate Therapeutics, Inc. is an equal opportunity employer. We value diversity and are committed to creating an inclusive environment for all employees.
About Fate Therapeutics, Inc.
Fate Therapeutics is a clinical-stage biopharmaceutical company dedicated to the development of first-in-class cellular immunotherapies for patients with cancer. The Company has established a leadership position in the clinical development and manufacture of universal, off-the-shelf cell products using its proprietary induced pluripotent stem cell (iPSC) product platform. The Company’s immuno-oncology pipeline includes off-the-shelf, iPSC-derived natural killer (NK) cell and T-cell product candidates, which are designed to synergize with well-established cancer therapies, including immune checkpoint inhibitors and monoclonal antibodies, and to target tumor-associated antigens using chimeric antigen receptors (CARs). Fate Therapeutics is headquartered in San Diego, CA. For more information, please visit www.fatetherapeutics.com.
Company
Fate Therapeutics is a clinical-stage biopharmaceutical company dedicated to bringing a first-in-class pipeline of induced pluripotent stem cell (iPSC)-derived cellular immunotherapies to patients with cancer and autoimmune disorders. Using its proprietary iPSC product platform, the Company has established a leadership position in creating multiplexed-engineered iPSC lines and in the manufacture and clinical development of off-the-shelf, iPSC-derived cell products. The Company’s effector cell pipeline includes multiplexed-engineered, iPSC-derived natural killer (NK) cell and T-cell product candidates, which incorporate novel synthetic controls of cell function, such as chimeric antigen receptors (CARs) to target tumor-associated antigens and are intended to deliver multiple mechanisms of therapeutic importance to patients including in combination with well-established cancer therapies. Fate Therapeutics is headquartered in San Diego, CA. For more information, please visit www.fatetherapeutics.com.
- Website
- http://www.fatetherapeutics.com/
- Phone
- 858.875.1800
- Location
-
12278 Scripps Summit Drive
San Diego
California
92131
United States
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