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Senior Research Associate, Cell Biology

Employer
Nurix Therapeutics
Location
San Francisco, CA
Start date
Nov 12, 2022

View more

Discipline
Regulatory, Science/R&D, Biology, Cell Biology
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Biotech Bay
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Job Details


Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.


Position

The Cell Screening group is seeking highly motivated individual with expertise in Pharmacology and Cell Biology to Nurix. The successful candidate will be responsible for cellular assay design and development as well as planning, execution and analysis of these assays to support discovery portfolio across the company. The individual will be a key member of the cellular screening team and generating critical cell lines and data package to support the progression of lead molecules into clinic. This individual will work closely with scientists from cross-functional disciplines and present the Cell Screening team to present data and interpretation to project teams. The ideal candidate will be self-driven, highly organized, highly detail oriented, and enjoy working in a dynamic team environment.


Required Qualifications

  • B.S. in Biology, Biochemistry, Pharmacology or related field with 5+ years of relevant industry experience or M.S. with 3+ years of experience
  • Hands-on experience with executing and analyzing quantitative medium-to-high throughput cellular assays to support small molecule drug discovery (e.g. BRET-based assays, luminescence assays)
  • Extensive hands-on experience with mammalian cell culture
  • Experience in assay development, optimization and troubleshooting
  • Familiarity with data analysis and publishing tools and using electronic notebook
  • Experience with CRISPR/Cas9 genome editing
  • Excellent in data presentation and communication to scientists across levels and functions
  • Strong organizational skills, attention to detail, and communication

Bonus Qualifications

  • Experience in lab automation, liquid handlers and semi-automated workflows is a strong plus

Fit with Nurix Culture and Values

  • Team-oriented and collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Find Us
Website
Phone
415-660-5320
Location
1700 Owens Street
Suite 205
San Francisco
California
94158
US
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