Sr. Director, Discovery Sciences & Technologies

Sr. Director, Discovery Sciences & Technologies
United States - California - Foster City

Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead’s therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.

Making an impact on a global scale
Inclusion is one of the company’s five core values. That’s because we know that we are stronger and more innovative at Gilead when we are informed by a diverse set of backgrounds, experiences and points of view. Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide.

When you join Gilead, you join our mission to change the world by enabling people to live healthier and more fulfilling lives. Come join a mission-driven bio-pharmaceutical organization that values inclusion and diversity, has a strong portfolio of products, and is constantly #CreatingPossible

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Job Description


We are seeking a highly qualified scientist and leader with extensive experience developing biochemical and cellular assays for target validation, lead discovery and in vitro pharmacology. The successful candidate will have a proven track record of drug discovery experience across small molecule and biologics modalities.

DST Department members are responsible for the design and execution of rigorous, quantitative, and physiologically-relevant in vitro biochemical and functional cellular assays. They collaborate within multi-disciplinary teams to discover and evolve drug candidates from HTS efforts during project inception to the characterization of the final development candidate

The successful candidate will be an integral member of the DST senior leadership team and work closely with various Research functions such as medicinal chemistry, protein therapeutics and DMPK across all therapeutic areas to advance transformational therapies into clinical development for patients. Gilead is a highly matrixed organization and the ability to work effectively across diverse stakeholders and therapeutic areas is a key attribute for this role.

Specific Responsibilities:

• Lead a team of assay development scientists supporting target discovery, small molecule and protein therapeutic lead discovery, profiling and characterization efforts across all Gilead's therapeutic areas.
  
• Mentor and supervise scientists and associates; providing scientific direction and guidance.
  
• Design assays and screening strategies for novel target discovery (siRNA and CRISPR), small and large molecule lead discovery and characterization efforts; identifying and implementing the most suitable technologies and proactively identifying rate-limiting steps and key decisional activities.
  
• Ability to identify and implement new assay technologies, methodologies, automation and analysis tools to enhance department capabilities and infrastructure to remain current and cutting edge for novel target discovery, biologics and small molecule drug discovery.
  
• Analyze large data sets and provide scientific insight and in-depth data interpretation to inform decision making at the project team and leadership levels.
  
• Ensure efficient use of resources to address all aspects of lead discovery and compound characterization.
  
• Manage several projects at any given time, work successfully in a cross-functional team environment and communicate clearly both verbally and in writing to a variety of audiences.
  

Minimum Qualifications:

• 15+ years' experience in a drug discovery environment with a PhD, in a related scientific discipline, with direct experience in assay development and high-throughput biology and screening.
  
• Broad experience with biochemical cell-based assay development to identify and characterize small molecules and biologics.
  
• Experience in immunology, flow cytometry and establishing physiologically relevant in vitro models using primary cells are desired.
  
• Training in genome engineering techniques, including CRISPR/Cas9-based cell line engineering and genome-wide and custom library-based screening are preferred.
  
• Demonstrated success for advancing multiple projects from HTS to lead optimization.
  
• Knowledge of mass spec approaches for lead discovery would be advantageous.
  
• The candidate should be able to think critically and creatively across multiple disciplines and have demonstrated the ability to solve research problems with experience in standard in vitro assays, including assay development, optimization, and troubleshooting.
  
• Experience in supervising direct reports at all levels including senior-level scientists. Effective group leadership skills are essential and enabling cross-functional collaboration and empowering people and developing and mentoring talent.
  
• Strong interpersonal and communication skills, with enthusiasm for leading in an environment characterized by rigorous scientific and innovative thinking.
  
• Excellent written, and oral organizational skills.
  

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As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@gilead.com for assistance.

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Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Gilead Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.






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