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Sr. Engineer I, Process Development

Moderna, Inc.
Norwood, MA
Start date
Nov 10, 2022

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Job Details

The Role:

The Pilot Scale Operations team is seeking a highly skilled and motivated full-time Sr. Engineer I to support nucleic acid pilot-scale production. Qualified candidates will have chromatography, enzymatic reaction, and tangential flow filtration expertise, and experience with scaling and technology transfer of these unit operations. A successful candidate should have experience in large and small-scale equipment maintenance and troubleshooting; as well as authoring and updating equipment specific SOPs. This position will require excellent communication and organizational skills, as well as a focus on operational excellence and process optimization. Candidates are expected to lead people and projects, often cross-functionally. A successful candidate must demonstrate the independent drive and collaborative spirit to operate in a dynamic, fast-paced environment.

Heres What Youll Do:

  • Be the receiving unit for technology transfer from Modernas Process Development teams, focusing on Nucleic Acid sciences, including DNA and mRNA

  • Be expected to lead other development scientists / engineers in defining process development and scale-up strategy, and implementing process control strategies

  • Operate, maintain, and trouble shoot reaction, tangential flow filtration and chromatography skids (AKTA and Axichrom)

  • Lead experiments to confirm robust process performance

  • Characterize Nucleic Acid properties through collaboration with analytical and technical teams.

  • Demonstrate and implement GLP best practices

  • Demonstrate process suitability and manufacturability through scale-up chromatography, enzymatic reaction, tangential flow filtration, and other technologies

  • Update and write standard operating procedure (SOPs) associated with Nucleic Acid production as needed

  • Assist Pilot Development Lab and technical teams with project goals, resourcing, and scheduling

  • Practice safe work habits and adhere to Moderna safety procedures and guidelines

  • Adhere to documented waste handling procedures to respect environmental regulations

Heres What Youll Bring to the Table:

  • Demonstrated success in Biologics/bioprocess development, technical problem solving, and tech transfer are essential

  • BS or MS in Bio/Chemical Engineering, Bio/Chemistry, or closely related field Basic understanding of Molecular Biology

  • 6 10 years of relevant industry experience in bioprocess development

  • Experience with synthesizing mRNA and/or DNA

  • Hands-on experience with chromatography, tangential flow filtration, normal flow filtration, and enzymatic reactions

  • Strong communication skills as you will be responsible for having multiple interactions across operating and development teams

Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:

  • Highly competitive and inclusive medical, dental and vision coverage options
  • Flexible Spending Accounts for medical expenses and dependent care expenses
  • Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities
  • Family care benefits, including subsidized back-up care options and on-demand tutoring
  • Free premium access to fitness, nutrition, and mindfulness classes
  • Exclusive preferred pricing on Peloton fitness equipment
  • Adoption and family-planning benefits
  • Dedicated care coordination support for our LGBTQ+ community
  • Generous paid time off, including:
    Vacation, sick time and holidays
    Volunteer time to participate within your community
    Discretionary winter shut down
    Paid sabbatical after 5 years; every 3 years thereafter
  • Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents
  • 401k match and Financial Planning tools
  • Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
  • Complimentary concierge service including home services research, travel booking, and entertainment requests
  • Free parking or subsidized commuter passes
  • Location-specific perks and extras!

Candidates should be aware that Moderna currently maintains a policy requiring all US-based employees to be fully vaccinated against COVID-19 and receive a booster shot once eligible. Newly hired employees must be vaccinated and boosted prior to their employment start date. Moderna is an equal opportunity employer and will provide a reasonable accommodation to those unable to be vaccinated or receive a booster where it is not an undue hardship to the company to do so as provided under federal, state, and local law.

About Moderna

In over 10 years since its inception, Moderna has transformed from a research-stage company advancing programs in the field of messenger RNA (mRNA), to an enterprise with a diverse clinical portfolio of vaccines and therapeutics across seven modalities, a broad intellectual property portfolio in areas including mRNA and lipid nanoparticle formulation, and an integrated manufacturing plant that allows for rapid clinical and commercial production at scale. Moderna maintains alliances with a broad range of domestic and overseas government and commercial collaborators, which has allowed for the pursuit of both groundbreaking science and rapid scaling of manufacturing. Most recently, Moderna's capabilities have come together to allow the authorized use and approval of one of the earliest and most effective vaccines against the COVID-19 pandemic.

Moderna's mRNA platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, and has allowed the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases, cardiovascular diseases and autoimmune diseases. Moderna has been named a top biopharmaceutical employer by Science for the past seven years. To learn more, visit

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a persons race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.




Moderna is advancing messenger RNA (mRNA) science to create a new class of transformative medicines for patients. Moderna’s platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, providing the Company the capability to pursue in parallel a robust pipeline of new development candidates. Moderna is developing therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases and cardiovascular diseases, independently and with strategic collaborators.

mRNA is now a turning point in the history of science, medicine, technology, even humankind itself. With this breakthrough discovery, many of the world’s biggest and most challenging medical problems are no longer a question of “how?” but merely a question of “when?”

Come with us as we pursue the uncharted reaches of possibility and make your mark on the future of medicine.


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