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Sr. Accountant

4D Molecular Therapeutics
Emeryville, California
Start date
Nov 10, 2022

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Administration, Accounting
Required Education
Bachelors Degree
Position Type
Full time
Biotech Bay, Best Places to Work
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Job Details

4D Molecular Therapeutics, Inc. (“4DMT”) is a clinical-stage gene therapy company pioneering the development of product candidates using targeted and evolved AAV vectors. 4DMT seeks to unlock the full potential of gene therapy using its platform, Therapeutic Vector Evolution, which combines the power of directed evolution with approximately one billion synthetic capsid sequences to invent evolved vectors for use in targeted gene therapy products. The company is initially focused in three therapeutic areas: ophthalmology, cardiology, and pulmonology. The 4DMT targeted and evolved vectors are invented with the goal of being delivered through clinically routine, well-tolerated and minimally invasive routes of administration, transducing diseased cells in target tissues efficiently, having reduced immunogenicity and, where relevant, having resistance to pre-existing antibodies. 4DMT has five active clinical trials: 4D-150 is a Phase 1/2 clinical trial for Wet AMD, 4D-125 is in a Phase 1/2 clinical trial for XLRP, 4D-110 is in a Phase 1 clinical trial for Choroideremia, 4D-310 is in a Phase 1/2 clinical trial for Fabry disease and 4D-710 is a Phase 1/2 clinical trial for Cystic Fibrosis.   4DMT is focused on attracting and retaining the best people in the industry who identify with our mission and innovative results-driven approach. We offer an inspiring and collaborative environment that encourages individual contributions, recognizes performance in multiple ways, offers competitive salary and benefits, and provides challenging opportunities for career development.  4D Molecular Therapeutics is located in Emeryville, CA.


The Senior Accountant will be primarily responsible for the preparation of various balance sheet account journal entries and reconciliations, internal/ external audit support, and SOX control documentation. This position will maintain an understanding of GAAP currently applicable to assigned area(s) and appropriately apply GAAP knowledge to assigned tasks. The Senior Accountant will understand and perform internal controls in compliance with established policies and procedures. Candidate will report to the Senior Accounting Manager. Position will be Hybrid, 2 days in Emeryville, CA headquarters, with the flexibility to work remote 3 days a week.



40% of Time: Responsible for all assigned account accruals and recons, which includes:

  • Prepare month end pre-clinical/ clinical R&D accruals, including review of CRO reports, patient costs and sites accruals
  • Prepare month end manufacturing cost accrual
  • Prepare corresponding monthly journal entries and related supporting documentation
  • Prepare monthly and quarterly accounts reconciliations
  • Review contracts and amendments monthly and analyze for impact on clinical/ CMO accruals
  • Work cross functionally with Clin Ops, Manufacturing, Research and Legal and other various business owners as well as external consultants
  • Work with external CROs and clinical /manufacturing vendors to ensure that accruals are accurately accounted for


25% of Time: Supports the ongoing preparations for Sarbanes-Oxley (SOX) compliance, which includes:

  • Support the maintenance of internal control documentation for the SOX compliance requirements
  • Ensure quarterly internal control is performed and reviewed by proper assignee per the company’s internal control narratives
  • Assist in providing information and documentation to external audit requests
  • Maintain current awareness and documentation of SOX compliance rules and regulations

25% of Time: Responsible for all cash reconciliations, which includes:

  • Prepare monthly investment security reconciliations and record journal entries
  • Prepare investment security compliance check per the company’s investment policy
  • Process weekly AP vendor payments
  • Perform monthly cash reconciliations, including maintaining bank statements

5% of Time: Responsible for performance and documentation of accounting policies and procedures for assigned area(s).

5% of Time: Assists internal and external auditors and state examiners, as applicable, by providing appropriate documentation and support when requested.

Other duties as assigned: flexible to be reassigned responsibilities upon workload and department adjustments/changes




  • Bachelor of Accountancy or equivalent required


  • Minimum of 5 years of related experience in the accounting field in industry or equivalent in public accounting required, 7 years of experience or equivalent preferred.


  • Experience with Sage Intacct preferred
  • CPA or working toward a CPA would be a bonus
  • Advanced skills in Microsoft Outlook, Excel, & Word required
  • Strong attention to detail and problem-solving skills
  • Excellent organization, communication and interpersonal skills required
  • Must be able to work independently
  • To maintain a healthy and safe workplace for all during the COVID-19 this role is expected to:
  • Work remotely and return on-site in 2022/2023 on a hybrid schedule
4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws.   Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities       Attention: Search Firms / 3rd Party Recruitment Agencies* The Talent Acquisition / HR team manages the recruiting for all positions at 4D Molecular Therapeutics. We will only accept resumes from a search agency/recruiter if we have a signed agreement in place and the Talent Acquisition / HR team has formally requested your help on a specific role. Unsolicited resumes sent to 4D Molecular Therapeutics will be considered property of 4D Molecular Therapeutics. 4D Molecular Therapeutics will not be responsible for any fees associated should we hire from unsolicited resumes.   Recruiters are requested not to contact or present candidates directly to our hiring managers or employees, and doing so may jeopardize eligibility to work on future positions. Recruiters interested in working with 4D Molecular Therapeutics can submit their information to– should we have a tough-to-fill role, we will contact you directly if you specialize in that area.


4DMT is a gene therapy company with a transformative discovery platform --Therapeutic Vector Evolution --that enables our “disease first” approach to product discovery and development, thereby allowing us to customize our AAV vectors to target specific tissue types associated with the underlying disease.

At 4DMT we are creating and developing optimized “biopharmaceutical grade” AAV vectors that will allow us uniquely to unlock the full potential of gene therapy. Our customized and proprietary AAV vectors are each designed, according to a 4DMT Target Vector Profile, to deliver genes to specific cells and tissues in the body to eradicate both rare and large market diseases.

While AAV gene therapy pioneers are making great strides with the first wave of products, hurdles still exist with the use of conventional vectors. The most commonly used AAV capsids (e.g., AAV2, 5, 8 and 9) were identified either 1) as contaminants in lab stocks of adenovirus, or 2) through monkey tissue processing. Therefore, these conventional vectors are not targeted specifically to any tissue in the body. This can lead to inefficient and non-specific delivery, thus requiring extremely high doses and potentially resulting in toxicities (including inflammation), high manufacturing burdens and suboptimal efficacy. In addition, suboptimal routes of delivery can be required for delivery to the right tissues (e.g., subretinal delivery to the retina). Finally, pre-existing neutralizing antibodies in many patients can limit efficacy, clinical trial enrollment and market sizes. 4DMT Innovation empowers us to create new and improved next generation AAV capsids to allow targeted delivery of our products by the optimal clinical route of administration.

At 4DMT we use our robust discovery platform, termed “Therapeutic Vector Evolution,” to create customized and proprietary gene delivery vehicles (novel AAV vectors) to deliver genes to specific tissues and cells in the body by the optimal route of administration. We use the power of evolution to create and refine these optimized vectors through genetic diversification and then natural selection in vivo.

4D Purpose Statement:  Boldly Innovating to Unlock the Full Potential of Gene Therapy for Countless Patients



  • Dare to Cure - Patients are waiting. Create big dreams for patients and take calculated risks to achieve them
  • Break Boundaries - Question the status quo and innovate beyond conventional approaches
  • Beyond Yourself - It's about patients, their families, our team, our families. We strengthen each other.
  • Prepare and Execute Relentlessly - Start with the end in mind, over-prepare and make contingency plans to your contingency plans

We invite all of you who share our passion and vision in creating the ultimate gene therapy products to cure genetic and rare diseases in children and adults. We seek the best people in the industry who identify with our mission and innovative results-driven approach. We offer an inspiring and collaborative environment that encourages individual contributions, recognizes performance in multiple ways, offers generous benefits and provides challenging opportunities for career development. 

Find Us
5858 Horton St. Suite 455
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