Director, Toxicology

Molecular Templates, Inc. (MTEM) is a clinical stage biopharmaceutical company focused on the discovery and development of biologic therapeutics for the treatment of cancer and other serious diseases. The company primarily develops a pipeline of therapies through its proprietary biologic engineered toxin body (ETB) drug platform with unique mechanisms of actions which are highly differentiated from antibody drug conjugates (ADCs). MTEM is developing MT-6402, which is in a Phase I clinical trial for PD-1/PD-L1 antibody relapsed/refractory patients; MT-5111, which is in a Phase I clinical trial for the treatment of HER2-positive cancers; and MT-0169, which is in a Phase I clinical trial to treat relapsed/refractory myeloma. Additional preclinical compounds derived from our ETB platform technology are being advanced toward clinical development.  Additional information about MTEM can be obtained at www.mtem.com.   

 

 

Position Overview: 

 

 

Seeking a motivated and experienced toxicologist with direct experience in non-human primate models. You will serve as the internal expert for the design and execution of non-human primate preclinical toxicology assessments.  Lead efforts working with both internal R&D colleagues and external partners to support and execute goals while able to handle a dynamic and fluid environment in support of efforts to bring new therapies to patients. 

 

 

Job Responsibilities: 

 

• Lead the toxicology function and serves as a project toxicologist in project teams 
• Design and oversee nonclinical toxicology programs (particularly nonhuman primate) and strategies to advance MTEM’s pipeline of ETB’s (non-GLP and GLP studies) 
• Lead the strategic plan and implementation of MTEM’s preclinical toxicology programs in collaboration with a range of internal and external partners 
• Work closely with cross-functional teams to ensure robust data is generated to support dose selection for clinical programs and ultimately BLA approvals 
• Partner with clinical and safety teams to conduct safety toxicity / safety assessments 
• Manage timelines for sample testing and data transfer with external vendors and/or internal teams 
• Lead investigative efforts into mechanisms of toxicity as needed 
• Single point of contact for all toxicology-related studies and strategy 
• Assist in the development and maintenance of a central biorepository database (e.g., Laboratory Information Management System) 
• Review and provide feedback on clinical study protocols, laboratory documents, and service provider laboratory scope of work documents for sample handling details 

 

 

Qualifications: 

 

 

• PhD in Toxicology, Biology, Pharmacology, or a related field, is highly preferred with five plus (5+) years’ experience in pharmaceutical or biotechnology industry, ideally in preclinical development and/or in basic research of therapeutics 
• Effective organization, planning, and time management 
• Expert knowledge of small and/or large molecule toxicology in Drug Development 
• Excellent critical thinking and scientific skills 
• Demonstrated ability to work effectively and collaboratively on cross-functional project teams 
• Flexibility and resilience are required to work in this dynamic environment 
• Proven ability to work under pressure and deadlines 
• Excellent communication and written skills 
• Proven productivity as demonstrated by publications/presentations/patents in key meetings or peer-reviewed publications 

 

 

Reporting Structure: 

 

This position does not have any supervisory responsibilities.  This role reports to the VP of Translational Medicine. 

 

 

MolecularTemplatescelebrates and supports our differences and is proud to be an Equal Employment Opportunity employer.  We do not discriminate based upon race, religion, color, national origin,sex(including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, veteran status, disability, or any other legally protected characteristic. 

 

MTEM is committed toprovidingreasonable accommodations for qualifiedindividuals. Ifyou needassistancewith your applicationdue to a disability, you may contact us at:careers@mtem.com. 

 

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