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Senior Scientist, Process Development - Upstream

Forge Biologics
Columbus, Ohio
Start date
Nov 6, 2022

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Job Details

Role Description:

We are currently seeking a Senior Scientist to join the Forge Biologics team. This is an exciting opportunity to lead efforts and characterize bioprocess methods to support viral vector manufacturing. The candidate will lead upstream biomanufacturing development and support upstream development in the manufacturing of viral vector for clients at various scales ranging from 500mL to 500L. The ideal candidate will be highly skilled in technical problem-solving and bioprocessing techniques to support our growth in the Gene Therapy sector.

This position reports to the Associate Director of Process Development and is responsible leading upstream process development activities for production of recombinant adeno-associated virus (rAAV) vectors. You will oversee and perform scalable maintenance, transfection, and infection of mammalian and insect cell lines in shake flasks and single-use bioreactors. Work activities will also include compiling experimental data, writing protocols and study reports, and presenting findings to internal and external parties with minimal supervision. It is expected that you will lead and participate as part of the process development team while accomplishing the timely completion of assignments and reporting of unexpected technical issues.



  • Independently design, execute, and analyze experiments optimizing production and purification of AAV
  • Directly supervise the upstream activities of the Process Development Lab – manage experiments, equipment, inventory, and workloads 
  • Maintain cell growth, transfection, and infection of mammalian and insect cells for baculovirus and rAAV manufacturing using shake flasks and single-use bioreactors
  • Assist in the downstream purification technologies related to rAAV purification using chromatography (affinity and ion-exchange) and filtration processes including microfiltration, depth filtration, tangential flow filtration, and sterile filtration as needed
  • Compile and review experimental data with minimal oversight and author publications, protocols, or reports
  • Support large-scale manufacturing runs and ensure timely delivery of materials to internal and external partners 
  • Delivering results in a high paced environment
  • Train and mentor junior laboratory technicians
  • Additional responsibilities not listed may be assigned as needed by leadership




  • Master’s Degree or higher in Chemistry, Chemical Engineering, Biochemistry, Biotechnology, or related and 8+ years’ experience, or PhD degree preferred, with 2+ years’ experience
  • Experience with suspension cell culture at all scales: flasks, bench-top bioreactors, and large-scale single-use bioreactors is required
  • Experience with upstream processing is preferred
  • Experience with purification of vaccines or viral vectors is preferred
  • Proficiency with MS Excel, GraphPad Prism, and electronic lab notebooks is essential 
  • Proficiency designing, executing, and analyzing DOE is highly desired
  • Must be self-motivating, organized and proactive
  • Strong technical aptitude including demonstrated experience in applying scientific reasoning to solve complex problems
  • Must have excellent verbal and written communication skills
  • Must have demonstrated experience effectively managing multiple projects and staff
  • Ability to work hours necessary to support development and/or product transfer activities
  • Must be able to work independently, but is also a team player with strong collaborative skills
  • In our commitment to safety of our employees and customers a COVID vaccination is required

Reporting Outline:

  • This position reports to the Associate Director of Process Development
  • Travel on an intermittent basis is required (approximately 5-10%) to support job responsibilities and commitments.



Forge is a gene therapy development engine, focused on enabling access to life changing gene therapies and helping bring them from idea into reality. We partner with innovators in the gene therapy community: scientists, physicians, biotech/pharma companies, and patient groups. We bring expertise in gene therapy manufacturing and therapeutics development to the table, helping champion teams that are navigating the long road from the lab bench to the bedside. With a patients-first approach, we are forging new models for working together to better accelerate these transformative medicines to reach those who need them most.

Find Us
3900 Gantz Rd
Grove City
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