Bioinformatics Analyst III

Manager:  Bioinformatics Scientist III
Department:  Bioinformatics
Location:  Richmond, CA Sangamo Therapeutics is a genomic medicine company building value with cutting-edge work across four distinct but complementary technology platforms – gene therapy, cell therapy, in vivo genome editing, and in vivo genome regulation. Using its deep scientific expertise and proprietary zinc finger genome engineering technology, Sangamo is working to create genomic cures for patients suffering from severe genetic diseases for which today’s medicines can only treat symptoms. At Sangamo, we are passionate about transforming lives by building a robust, sustainable, differentiated, innovative, and high value genomic medicine pipeline that addresses patients with life-limiting conditions. Sangamo takes pride in being the first to edit endogenous human genes, first to treat patients with gene edited T cells, and first to treat patients with in vivo genome editing. Our top priority is to meet the needs of patients with commitment and compassion. Along with our commitment to science and to our patients, we also endeavor to create an inclusive environment that promotes and values diversity. Sangamo is a company where individuals can flourish, grow, and develop their expertise.

 

We are seeking top talent to join our mission.  Let’s build a better future together.

 

JOB SUMMARY:   

Sangamo Therapeutics is seeking a Bioinformatics Analyst III to work on functional genomics data to support the development of therapeutic clinical leads. The qualified candidate will provide guidance to the project by helping design gene expression experiments, writing analysis software, and interpreting results.  Duties also include creation and support of web tools for wet lab exploratory data analysis

 

ESSENTIAL FUNCTIONS:

Support and enable gene expression (Affymetrix, bulk RNASeq, single-cell/muclei RNASeq) and NGS experiments by writing code that generates robust, interpretable, actionable items from sequencing data

Support genomics activities in cross-functional therapeutics setting Work in collaboration with cellular/molecular biologists to design functional genomics experiments in therapeutic target selection Perform computational analyses to answer relevant biological questions Generate and test hypotheses on genome-scale data using analytical and statistical methods Query and integrate data from public omics resources to enable decision making Maintain pipelines for analysis and display of sequencing data  

EDUCATION, EXPERIENCE AND SKILLS REQUIREMENTS:

Must have MS (with 4-5 years of relevant experience) or PhD (with 3-4 years of relevant experience) in Bioinformatics, Computer Science, Statistics, Bioengineering or related area Strong background with NGS platforms and analysis (Illumina, Affymetrix, bulk RNAseq, single-cell sequencing, etc). Strong background in statistical and machine learning methods Experience with AAV sequencing Understanding of molecular biology processes, mammalian/viral genomes, and large-N experiments Proficiency with handling large-scale data in a Linux and/or cloud environment (e.g., AWS) Proficiency with development and application of computational methods to characterize on-/off-target, translocation, and gene expression profile of gene-edited cellular products Excellent Python & R programming skills Strong sense of responsibility for generated data Understanding of molecular biology processes Excellent communication skills Familiarity with common NGS/genomics formats and resources (NCBI, UCSC, EnsEMBL) Familiarity with at least one scientific/statistical graphics programming environment (ggplot2, dash, matplotlib, scipy, seaborn, D3.js, etc) Git source code management experience  

OTHER QUALIFICATIONS:

Experience with non-Illumina sequencing platforms (PacBio, Oxford Nanopore, Ion Torrent) Experience with basic web forms Experience with Docker Familiarity with CAR-Tregs Familiarity with SQL and/or noSQL databases

 

Sangamo is an equal opportunity employer

Sangamo is committed to fostering belonging for all employees and embraces diversity, equity, and inclusion in recruiting and hiring.  All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual’s race, color, sex, gender identity, gender expression, religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws

 

Commitment to Safety

Sangamo requires all U.S. workers to be fully vaccinated against COVID-19 as of their start date.  This requirement is a condition of employment at Sangamo, and it applies regardless of location or classification of role.  If you are unable to receive the vaccine & booster, you will have an opportunity to request a reasonable accommodation consistent with applicable laws.

 

Note to External Recruiters: We do not accept unsolicited resumes from any source other than from the candidates themselves.