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Research Engineer

Gladstone Institutes
San Francisco, CA
Start date
Oct 5, 2022

View more

Regulatory, Research/Documentation, Science/R&D, Research
Required Education
Bachelors Degree
Position Type
Full time
Biotech Bay
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Job Details

Lab/Area:Finkbeiner Lab


We are looking for a Research Engineer to join the Center for Systems and Therapeutics. The candidate will be a critical member of a team of biologists and engineers to maintain and develop our cutting-edge automated microscopy platform. We are seeking someone who is passionate about engineering, imaging, deep learning and biology. This person will work closely with many other scientists towards common microscopy and engineering goals that are driven by the pursuit of unraveling neurological diseases.

About our group and the position:

We are an academic lab with over 20 BS-, MS-, and PhD-level neuroscientists and engineers that study neurodegenerative diseases such as ALS, Huntington’s disease, Parkinson’s disease, Alzheimer’s disease and other dementias. We use different cellular model systems, including human stem cells that are derived from patients, to answer basic questions in neuroscience as well as discover new therapies for these neurodegenerative diseases. At the core of our research is a novel longitudinal imaging system that we have invented to collect images and time-lapse movies of fluorescent labeled neurons in a high throughput format. We use our microscopy system to extract various types of information about how patient stem cell derived neurons grow, function, degenerate, and respond to candidate drugs. We also take advantage of the terabytes of data that we generate every day and use deep learning to invent new methods for analyzing our images. We have collaborations with many industry and academic groups, publish our work in high profile scientific journals, and present our work at national and international conferences. We continue to design and build novel automated microscopy systems and we need your help to do it.

Teamwork is essential for our success. You will work as part of a team to design, build, and maintain our robotic microscopes as well as help the biologists in the lab utilize these unique microscopes in their research. If you enjoy working with people, learning new exciting science, tinkering with optics and electronics, and want to creatively design and build things, this would be a great fit for you.

Education Required:

Minimum: B.S. in Physics, Optical or Biomedical Engineering, Computer Science or related field with 1-2 years of relevant research experience

Required Education/Skills:

  • Experience with epifluorescence and/or spinning-disk confocal microscopy

  • Critical thinking and attention to detail

  • Knowledge of one or more of the following languages: Python, Java, C++, Matlab, R

  • Highly organized with excellent communication skills

  • Highly independent and self-motivated

  • Able to work effectively in small groups

  • Interest in biology, engineering, and getting involved with the customization of microscopes

  • Able to communicate highly complex concepts to and work with those of different backgrounds

Education/Skills/Experience Preferred:

  • Higher education in Physics, Engineering, or related field

  • Conversant knowledge of imaging hardware (e.g., CMOS/sCMOS cameras, optical filters, objectives)

  • Experience in maintaining microscope systems (e.g., cleaning, calibration, alignment)

  • Experience in building microscope systems

  • Experience with robotics or automation

  • Experience with MicroManager or other microscope control software

  • Experience with biological image analysis software, such as ImageJ

  • Familiarity and interest in neurodegenerative diseases

  • Presentation of original research to a large audience

  • Poster presentation of original research at conferences

  • Publications of original research in primary scientific literature

Additional Information:
  • Title and salary will be commensurate with education and experience.
  • Gladstone is an equal opportunity employer.


Gladstone is an independent, nonprofit life science research organization located in the epicenter of biomedical and technological innovation in the San Francisco Bay Area. Gladstone has created a research model that disrupts how science is done, funds big ideas, and attracts the brightest minds. Gladstone Institutes leads the way for innovative research in the biomedical field. We always seek dedicated and talented individuals to join our team.

Scientists know that using a diversity of approaches is often the most efficient strategy for solving a problem. New and different perspectives engender the very innovation that Gladstone prizes. This is one of the many reasons why we value diversity at Gladstone—be that a diversity of race, culture, religion, mental or physical ability, heritage, age, gender, sexual orientation or other characteristics. Our employees hail from more than 30 countries around the globe and we seek to hire the best and brightest for our diverse team of scientists and administrators. Career opportunities are available in both our administrative offices and our research areas.

Our Benefits
Gladstone offers eligible employees—and their dependents—a comprehensive range of benefits, including health insurance, retirement savings, and professional development.


  • Health and Retirement
    • A choice of medical plans, flexible spending account, and retirement account options that include employer contributions help you take care of your health and your future.
  • Time Away from Work
    • More than just vacation days, our paid and unpaid leave policies offer flexibility to help you confront different stages of life including maternity and paternity leave, as well as other types of family leave.
  • Professional Development
    • Gladstone encourages employees to seek the skills they need to remain at the forefront of their profession. By supporting professional development workshops and continuing education, Gladstone provides employees with the resources they need to evolve in their role and in their career.
  • Gladstone Cares
    • A specially selected suite of benefits to support you in and out of the workplace. Includes resources for dealing with the many stages of life to specific coverage for family planning, and back-up child or elder care coverage.
Find Us
1650 Owens Street
San Francisco
United States
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