Senior Scientist, Cancer Immunotherapy (Antibody & CAR Development)
- Employer
- Fate Therapeutics
- Location
- San Diego, CA
- Start date
- Oct 4, 2022
View more
- Discipline
- Science/R&D, Biotechnology, Immunology, Oncology
- Required Education
- Doctorate/PHD/MD
- Position Type
- Full time
- Hotbed
- Biotech Beach
Job Details
Responsibilities
- Provide scientific and technical support to identify, evaluate, and advance novel binders for development of targeted therapies including CARs.
- Manage and provide oversight for Fate’s binder discovery initiatives (CRO management, antibody characterization, etc.)
- Develop and execute screening methodologies and assays for evaluating the biophysical properties of candidate binders (i.e., affinity, specificity/cross-reactivity, aggregation, stability, etc.).
- Design and generate plasmid constructs, lentivirus, and cell line tools as needed.
- Develop and execute experimental plans to collaborate with other teams and to meet program objectives and timelines.
- Provide strategic direction and oversee implementation of binder identification and screening pipelines
- Communicate research and development findings in cross-disciplinary team meetings as well as with external partners.
Qualifications
- PhD in Molecular Biology, Biochemistry, or related fields with 7+ years postdoctoral and industry experience is highly preferred.
- In-depth experience with antibody/binder generation, screening, and characterization (specificity, affinity, epitope binning, aggregation, stability, etc.)
- Extensive experience in molecular cloning, vector construction, lentivirus production/transduction, and transgene expression.
- Antibody and protein characterization and assay development (ELISA, cell binding, Biacore/Octet, HPLC, SDS-PAGE) is preferred.
- Protein expression in mammalian systems (CHO or 293) and protein purification (FPLC, protein A, affinity column) experience is a plus.
- Extensive experience in cell culture and assay development (primary and tumor cell culture, transfection, viral transduction, multi-color flow cytometry, FACS, reporter assay).
- Experience with gene editing technologies including gRNA design, donor template building, and knock-in analysis is a plus.
- Experience with CAR design, iPSCs, T and NK cells is plus.
- Comfortable in a fast-paced environment and able to adjust workload based upon changing priorities.
- Ability to design, optimize, and perform experiments in a high-throughput manner is a plus.
- Demonstrated success in working in a cross-functional team environment.
- Excellent organizational skills with record keeping abilities.
Working Conditions and Physical Requirements
- Will require working with blood and cell lines of human and animal origin
- Will require working with hazardous materials
- 100% on-site work at corporate headquarters and research facilities in San Diego, CA
- Occasional evening and weekend work will be required
The preceding job description indicates the general nature and level of work performed by employees within this classification. Additional and incidental duties related to the primary duties may be required from time to time.
About Fate Therapeutics, Inc.
Fate Therapeutics is a clinical-stage biopharmaceutical company dedicated to the development of first-in-class cellular immunotherapies for patients with cancer. The Company has established a leadership position in the clinical development and manufacture of universal, off-the-shelf cell products using its proprietary induced pluripotent stem cell (iPSC) product platform. The Company’s immuno-oncology pipeline includes off-the-shelf, iPSC-derived natural killer (NK) cell and T-cell product candidates, which are designed to synergize with well-established cancer therapies, including immune checkpoint inhibitors and monoclonal antibodies, and to target tumor-associated antigens using chimeric antigen receptors (CARs). Fate Therapeutics is headquartered in San Diego, CA. For more information, please visit www.fatetherapeutics.com.
Company
Fate Therapeutics is a clinical-stage biopharmaceutical company dedicated to bringing a first-in-class pipeline of induced pluripotent stem cell (iPSC)-derived cellular immunotherapies to patients with cancer and autoimmune disorders. Using its proprietary iPSC product platform, the Company has established a leadership position in creating multiplexed-engineered iPSC lines and in the manufacture and clinical development of off-the-shelf, iPSC-derived cell products. The Company’s effector cell pipeline includes multiplexed-engineered, iPSC-derived natural killer (NK) cell and T-cell product candidates, which incorporate novel synthetic controls of cell function, such as chimeric antigen receptors (CARs) to target tumor-associated antigens and are intended to deliver multiple mechanisms of therapeutic importance to patients including in combination with well-established cancer therapies. Fate Therapeutics is headquartered in San Diego, CA. For more information, please visit www.fatetherapeutics.com.
- Website
- http://www.fatetherapeutics.com/
- Phone
- 858.875.1800
- Location
-
12278 Scripps Summit Drive
San Diego
California
92131
United States
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