Scientist / Senior Scientist – iPSC and Cell Engineering

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Adicet Bio, Inc is a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for cancer. We are advancing a pipeline of “off-the-shelf” gamma delta T cells, engineered with chimeric antigen receptors (CAR) and T cell receptor-like antibodies (TCRL), to enhance selective tumor targeting, facilitate innate and adaptive anti-tumor immune response, and improve persistence for durable activity in patients. Our approach to activate, engineer and manufacture allogeneic gamma delta T cell product candidates derived from the peripheral blood cells of unrelated donors allows us to generate new product candidates in a rapid and cost-efficient manner. For more information, please visit our website at http://www.adicetbio.com.

We are seeking a highly motivated Scientist / Senior Scientist with a strong background in T cell biology to join our iPSC and Cell Engineering Team. The successful candidate will be part of a cross-disciplinary team responsible for exploring novel pursuits across the iPSC and Cell Engineering landscape. Focused activities will include the redifferentiation and characterization of immune effector gamma delta T cell populations derived from existing dedifferentiated iPSC banks. In addition, the successful candidate will be responsible for integration and rigorous characterization of novel cell engineering technologies to enhance gamma delta T cell effector functions.

Key responsibilities:

• Independently design and execute studies to optimize methods for iPSC differentiation into functional gamma delta T cells
• Develop and establish assays to characterize the molecular and functional phenotype of iPSC-derived gamma delta T cells
• Investigate novel cell engineering technologies to functionally enhance the efficacy of gamma delta T cells
• Analyze and interpret experimental data and summarize key findings to drive critical decision making.
• Collaborate across functional groups, manage multiple projects while adhering to timelines
• Provide mentorship and support to direct reports and other team members

Qualifications:

• Ph.D. in Immunology, Tumor Immunology, or related field with a minimum of 3+ years of post-doctoral or industry experience
• Strong background in T cell biology including differentiation, activation pathways, and effector mechanisms
• Knowledge and experience with iPSC reprogramming and differentiation into T cells
• Experience with viral and non-viral gene editing techniques in primary T cells
• Expertise with molecular and immunological assays to characterize T cell molecular and functional phenotypes and including, but not limited to, PCR/qPCR/ddPCR, RNA-Seq, multiparameter flow cytometry, cytokine release assays, and cytotoxicity assays
• Excellent interpersonal, verbal, and written communication skills
• Strong management skills and ability to create, influence, and lead a team
• Self-motivated, innovative mindset, and focused; able to collaborate with colleagues to accomplish project goals

Adicet Bio requires all workers to be fully vaccinated against COVID-19, including the booster dose.

BENEFITS:

Adicet Bio offers both comprehensive benefits and Paid Time (PTO) plans for employees, which begin on the first day of employment, as well as the opportunity to work in a growing, dynamic environment.

Adicet Bio is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.