Senior Scientist - In Vitro Pharmacology

Company Background:

Century Therapeutics is developing novel allogeneic living cell products for oncology that overcome the limitations of current cell therapies. Century's genetically-engineered, universal iPSC-derived immune effector cell products are designed to specifically target hematologic and solid tumor cancers. Our commitment to developing off-the-shelf cell therapies will expand patient access and provide an unparalleled opportunity to advance the course of cancer care.

Century's foundational technology is built on induced pluripotent stem cells (iPSCs) that have unlimited self-renewing capacity. This enables complex cellular engineering to produce controlled cell banks of modified cells that can be expanded and differentiated into desired immune effector cells, which can supply vast amounts of allogeneic, homogeneous therapeutic products. This platform differentiates Century from other approaches that utilize non-renewable donor-derived cells.

Role

The Sr. Scientist will be part of Century's In-Vitro Pharmacology team and will be responsible leading a small team focused executing in-vitro functional assays to assess the functionality and fitness of our iPSC derived cell therapy products. The ideal candidate will have expertise in acute myeloid leukemia (AML). Direct experience with cytotoxicity assays and multi-color flow cytometry is essential. Experience with MSD or ELISA preferred.

Responsibilities:

• Lead in vitro pharmacology effort for therapeutic program
• Manage small team of associates
• Functional assessment of cell products (Cytotoxicity, Persistence, Serial Killing, and Cytokine Secretion/MSD.)
• Cell culture (primary cells and immortalized tumor cells)
• Multi color flow panel design
• Phenotypic characterization of cell products
• Assay development
• Drafting technical reports
• Presenting results internally and externally

Qualifications:

• Typically, a PhD in biological, technical, or engineering field with 4-6 years post-doc/industry experience. Or a BS or MS degree in a relevant biological, technical, or engineering field, with 12+ years for BS, or 10+ years for MS, of relevant professional experience
• Strong background in tumor biology or immunology
• Experience with acute myeloid leukemia (AML) strongly preferred
• Demonstrated record of developing and optimizing various functional assays
• Hands on knowledge of multi color flow cytometry and panel design (8+ color)

Requirements:

• Open communicator willing to ask questions and troubleshoot with colleagues
• Detail-oriented with data-driven problem-solving skills
• High degree of scientific integrity with a commitment to ethics and scientific rigor
• Excellent written and verbal communication skills
• Willingness to lead a small team of highly motivated scientists conducting innovative, fast-paced experiments
• Industry experience strongly preferred

Century Therapeutics Inc. is an Equal Employment Opportunity/Affirmative Action Employer - Minority/Female/Disability/Veteran. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or veteran status or any other characteristic protected by federal, state, or local law.