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Sr Research Associate, or Technical Scientist in Analytical Development and Automation

BioMarin Pharmaceutical Inc.
Novato, California
Start date
Sep 30, 2022
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Who We Are

For more than two decades, going our own way has led to countless breakthroughs, bettering the lives of those suffering from rare genetic disease. In 1997 we were founded to make a big difference in small patient populations. Now we seek to make an even greater impact by applying the same science-driven, patient-forward approach that propelled our last 25 years of drug development to larger genetic disorders, as well as genetic subsets of more common conditions. Through our unparalleled expertise in genetics and molecular biology, we will continue to develop targeted therapies that address the root cause of the conditions we seek to treat. Applying our knowledge to make a transformative impact is not just a calling, but an obligation to those who will benefit most. The end goal has always been better lives and now we can reach more.

And the more people we reach, the more our impact can grow. We transform lives through genetic discovery.

Our Culture

Our desire to make a positive impact on our patients extends to our employees and BioMarin is committed to fostering an inclusive environment where every person feels seen, valued, and heard – so employees can thrive in all areas of their lives, in and outside of work. We seek to provide an open, flexible, and friendly work environment to empower people and to provide them with the ability to develop their long-term careers. Ultimately, we want to be an organization where people enjoy coming to work and take pride in our efforts to help patients.

BioMarin’s Technical Operations group is responsible for creating our drugs for use in clinical trials and for scaling production of those drugs for the commercial market. These engineers, technicians, scientists and support staff build and maintain BioMarin’s cutting-edge manufacturing processes and sites, provide quality assurance and quality control to ensure we meet regulatory standards, and procure the needed goods and services to support manufacturing and coordinating the worldwide movement of our drugs to patients. Come join our team and make a meaningful impact on patients’ lives.


The Analytical Sciences department at BioMarin Pharmaceutical Inc. is seeking a Sr Research Associate, or Technical Scientist in Analytical Development and Automation to join a mass spectrometry-based team focused on supporting oligonucleotide, small molecule, gene, and enzyme replacement therapies. The successful candidate will be a self-motivated, independent, and agile scientist who has proven ability to work in a multi-disciplinary and fast-paced environment.

The primary set of responsibilities will be LC and LC/MS based product characterization and analytical method development to support clinical-phase development and commercial process transfer/investigations/optimizations. The selected candidate should possess excellent organizational, analytical and communication skills and be a self-starter willing to work efficiently and collaboratively in a dynamic environment. 

An ideal candidate will have significant experience in HPLC, Mass Spectrometry based assays, analytical method development, and data handling. A good scientific understanding of protein chemistry and biochemistry is essential. Hands-on experience in oligos and small molecules with a prior knowledge of ICH and regulatory submission is a plus.


Development and execution of primarily LC and LC/MS based analytical methods for the development and characterization of oligonucleotides, small molecules and biologics at different clinical stages.

  • Development of analytical methods using size exclusion, ion exchange, reverse phase chromatograms and capillary electrophoresis.
  • Provide the data in a quality presentation form (methods, qualification report, development report, memo, comparability report, etc) to support regulatory submissions.
  • Present data proactively and regularly in group and department meetings.
  • Track progress against project timelines, generate regular status updates and communicate progress and issues to manager.
  • Document experiments, data, and findings electronically in an accessible manner for inspections.
  • Participate in the general lab and instrument maintenance.


 Required Skills:

  • Expertise in separations science, including but not limited to: RP, IEX, SEC, HILIC, and HIC
  • Expertise in mass spectrometry, including ESI and MALDI ionization with a range of mass spectrometer designs (Q-TOF, Orbitrap, QQQ), and standard chromatographic detectors (UV, FLR, ELSD, CAD, RI, MALS)
  • Hand-on experience in protein biochemistry (g. SDS-PAGE, Western Blot, Immunoprecipitation)
  • Strong organizational and communication skills and effective interpersonal skills
  • Ability to learn new technologies fast with good problem-solving skills
  • Proven technical skills in a cross-functional and collaborative environment
  • Proven flexibility and execution skills to deliver in a fast-paced, multi-tasking environment
  • Experience in automation  

 Desired Skills:

  • Experience in chromatography and mass spectrometry.
  • Knowledge of biopharmaceutical development.
  • Knowledge of oligos and small molecules development is a plus.


MS degree in Biology, Chemistry or related field with 6+ years of relevant experiences for Sr Research Associates, or 8+ years of relevant experiences for Technical Scientist.


Will report to a PhD Scientist in Analytical Sciences.



PLEASE NOTE: Absent a Medical or Religious reason that prohibits vaccinations, all our incoming employees must be vaccinated for COVID-19.

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.
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