Associate Scientist I/II, Plasmid Process Development

We are currently seeking an Associate I/II Scientist, Plasmid Process Development to join the Forge Biologics team. This is an exciting entry-level opportunity to assist in the execution of laboratory experiments and protocols for downstream process development efforts. The candidate will assist in process development protocols/studies to optimize procedures for unique plasmid production platform process and to assist in the production of client materials. The Associate Scientist I/II will work to meet production goals, notify management of any potential delays in the schedule, and make recommendations to resolve the issues.

This position reports to Associate Director, Plasmid Process Development and is responsible for laboratory stocking, inventory management, and assisting in laboratory activities. This includes preparing growth media, chemical buffers, solutions, or other reagents that involve the mixing of subcomponents and preparing raw materials for use in production steps. Work activities may also include performing laboratory techniques (plasmid purification and microbial fermentation) in support of production of plasmid materials. It is expected that you will work as a member of the development team while accomplishing the timely completion of assignments and reporting of unexpected technical issues.

Responsibilities:

• Assist with overall maintenance of the production and testing facilities. This includes but may not be limited to performing quality systems checks, buffer preparation, autoclaving of media, packing of biohazard material, monitoring or sanitizing equipment, preparing facility for production campaigns, and periodic cleaning of incubators, centrifuges, FPLCs, biological safety cabinets (BSCs), and other equipment
• Culturing cells, performing plasmid transformations of microbial cells, harvesting and lysing cells, and purifying plasmid using FPLC, TFF or other techniques
• Provide support in the receipt and distribution of incoming raw materials for research, preclinical, and clinical manufacturing
• Unpack reagents, maintaining proper cold storage, restock supplies in storerooms or laboratories
• Quarantine and prepare incoming raw materials intended for preclinical or clinical manufacturing for inspection and release
• Assist in maintaining proper inventories of raw materials and consumables
• Prepares formulations and raw materials as specified in protocols without the introduction of contaminants
• Prepare sterile reagents as dictated by procedures or management by filtration or steam autoclaving
• Maintains clean work environment in all work areas
• Reports any discrepancies from protocols/study procedures or any materials preparation problems to management
• Delivering results in a high paced environment
• Package and ship finished product to clients in accordance with procedures and regulations
• Additional responsibilities not listed may be assigned as needed by leadership

Requirements:

• Bachelor’s degree in Biology, Chemistry, or relevant area; Associate’s degree with 2 years of relevant experience may be considered
• Knowledge of any of the following techniques is preferred: bacterial transformation, fermentation, bioreactor operation, tangential flow filtration, chromatography, and depth filtration.
• Must be self-motivating, organized and proactive
• Strong technical aptitude including demonstrated experience in applying scientific reasoning to solve problems
• Strong writing, verbal, and organizational skills are essential
• Ability to work hours necessary to support production and/or product transfer activities
• Ability to work in loud noise environments and in Personal Protective Equipment (PPE) and cleanroom gowning attire as needed
• Ability to lift 50 lbs
• In our commitment to safety of our employees and customers a COVID vaccination is required.