We are currently seeking a Senior Research Associate, mRNA Technologies who will be conducting research and early development activities for mRNA design and production at Mammoth. In this role, the successful candidate will be contributing to the mRNA implementation of Mammoth’s proprietary CRISPR nuclease systems, supporting the design and production of candidates for a variety of therapeutic indications.KEY RESPONSIBILITIES
- In-house research-scale production and quality control of test articles to support Mammoth’s ex vivo and in vivo studies
- Establish methodologies to produce, purify, and quality control mRNA candidates for multiple therapeutic programs
- Produce test articles to support therapeutic programs according to quality criteria and timelines
- Other duties as required
- Bachelor’s degree in Biology, Chemistry or related discipline with 2+ years of experience or Masters degree in related discipline
- Relevant research in an industry or academic setting, with a focus on mRNA therapeutics or RNA biology
- Experience with in vitro transcription systems, cloning, enzymatic reactions, purification, optimization, and quality assessment
- Experience in a broad range of nucleic acid detection and characterization methodologies (e.g., HPLC, RT-PCR, etc.)
- Experience in mRNA drug development and/or platform development
- Experience with automated platforms and process development
- A foundation in experimental documentation, basic statistical analysis and data presentation
- Excellent oral and written communication skills
- Company-paid health/vision/dental benefits
- Unlimited vacation and generous sick time
- Company-sponsored meals and snacks
- Wellness, caregiver and ergonomics benefits
- 401(k) with company matching
Mammoth Biosciences is harnessing the diversity of life to power the next generation of CRISPR products. Through the discovery and engineering of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. Mammoth aims to develop permanent genetic cures through best-in-class in vivo and ex vivo therapies and to democratize disease detection with on-demand diagnostics. Mammoth can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Based in the San Francisco Bay Area, Mammoth Biosciences is co-founded by CRISPR pioneer and Nobel Laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Redmile Group, Foresite Capital, Senator Investment Group, Sixth Street, Decheng, Mayfield, NFX, and 8VC, along with leading individual investors including Brook Byers, Tim Cook, and Jeff Huber.
Our small-size proteins, such as Cas14 and CasPhi, are poised to transform disease treatment enabling novel editing approaches and delivery options that are difficult to achieve or not even possible with previously described CRISPR-Cas systems. Our teams are responsible for discovering and engineering novel CRISPR systems, establishing CRISPR-based diagnostics, and translating our unique CRISPR technology into therapeutic treatments with the ultimate goal of cures for indications with high medical need.
It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation. Mammoth Biosciences requires that all employees be vaccinated against Covid-19 as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law.