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Associate Director – Bioconjugation

Employer
BioSpace Recruitment Services
Location
02140, Cambridge
Start date
Sep 29, 2022

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Discipline
Science/R&D, Biology, Chemistry, Research, Laboratory
Required Education
Doctorate/PHD/MD
Position Type
Full time
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We are seeking an experienced and highly creative Associate Director/Director who will lead the pipeline bioconjugation efforts. The successful candidate will have a strong background in chemistry or biochemistry and a passion for driving drug discovery projects.

 

 Principle Duties and Responsibilities:

  • Manage multiple CROs in the preparation, characterization and stability testing of antibody drug conjugates. Trouble shoot reactions and ensure that required conjugates are delivered to internal stakeholders and potential collaborators on time and within specifications.
  • Hire and train lab staff in a wide range of bioconjugation and protein purification techniques. Work closely with medicinal chemistry team to advance ADCs from hit to lead, and lead optimization to candidate selection with an eye toward improving conjugation process and analytical characterization methods.
  • Present written and oral reports to multidisciplinary teams.
  • Contribute to the build-out and upkeep of an expanding laboratory through maintaining shared equipment, assisting with general laboratory housekeeping in collaboration with our Lab Manager, and developing processes for improving workflow efficiency.

 

Skills, Abilities & Competencies:

  • Hands-on experience with preparation, purification, and characterization of antibody drug conjugates required
  • Strong CRO management skills preferred; experience mentoring scientific staff preferred
  • Demonstrated knowledge of various techniques and troubleshooting abilities related to producing ADCs on microgram to gram scale (site-specific, rebridging, lysine, etc, HIC, SEC, AKTA FPLC, mix mode HPLC, UF/DF, high-throughput/microscale conjugation, LAL, UV-VIS, etc). Demonstrated creativity in novel bioconjugation strategies desired.
  • Clear communication and presentation skills; desire to represent the client to external stakeholders in areas related to bioconjugation.
  • Enthusiasm for collaborating with multidisciplinary teams of chemists, protein engineers, and biologists
  • Proficiency with operating common laboratory equipment and maintaining laboratory infrastructure

 

Education:

  • BS/MS in chemistry, biochemistry, or a related field with 8-10+ years lab experience; PhD with 5-10 year industry experience preferred
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