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Associate Scientist, Platform Biology (Biophysics)

Employer
Arvinas Inc.
Location
New Haven, CT
Start date
Sep 29, 2022
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Job Details

Arvinas is a clinical-stage biopharmaceutical company leading the way in targeted protein degradation therapeutics. Arvinas is the first company to focus solely on protein degradation and its platform technology is the most advanced in the field. Since its founding in 2013, Arvinas’ PROTAC® Discovery Engine has been driving the most significant breakthroughs in the industry. Arvinas’ pipeline encompasses a range of validated and undruggable targets in oncology, immuno-oncology, and neuroscience. This includes three clinical-stage programs: bavdegalutamide (ARV-110) and ARV-766, which are being developed as potential treatments for men with late-line metastatic castrate-resistant prostate cancer, and ARV-471, which is being developed as a potential treatment for patients with breast cancer.

#TeamArvinas is made up of more than 350 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and purpose – to improve the well-being of patients and families impacted by the devastating diseases Arvinas is working to treat. It’s an exciting time to be in drug development and it’s an exciting time to be at Arvinas. But don’t just take our word for it – here’s what Arvinas employees are saying. For more information, please visit www.arvinas.com.

 

Position Summary

This position of Senior Associate Scientist, Biophysics, will serve as point of contact for multiple programs, working directly with biology and chemistry leads. As point of contact, this position will be responsible for the generation, analysis and summary of their own data as well as tasked with summarizing the overall data package generated from multiple biophysical and/or biochemical assays. This position will serve to communicate findings and make data driven recommendations to project leads together with hiring manager.

This position reports to Senior Research Scientist and will be located at our headquarters in New Haven, CT.

 

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Utilization of assay design techniques, quality control and execution of medium- to high- throughput 96/384 well assay formats, such as SPR, MST and SS
  • Partner with diverse project teams in complex scheduling of work and generation of data in support of drug discovery and development programs.  Troubleshoot through technical and scientific challenges in order to deliver critical data.
  • Serve as project point of contact for biology and chemistry leads to summarize all in vitro data findings, recommend additional mechanism of action experiments, provide project updates at team meetings, prioritize compound screening funnels
  • Design and execution of complex experiments including but not limited to: binding affinity, binding kinetics, compound screening, protein-protein interactions, and protein quality control
  • Drive programs toward go/no-go decisions on compound series through generation of robust and reproducible data package

Qualifications

  • Minimum of two years laboratory experience
  • A strong work ethic and willingness to learn drug discovery approaches and biochemical and biophysical techniques, is a requirement. Strong theoretical knowledge in biophysics and biochemistry is a preferred. 
  • Knowledge and theory behind protein expression, recombinant protein expression would be a plus
  • Understanding of cancer biology, biochemistry, and cellular biology is desirable.
  • Excellent data handling and recording skills as well as oral and written communication skills.
  • Work as a team player and be able to multitask.
  • Ability to work and problem-solve independently while under general supervision by the Senior Research Scientist.
  • Demonstrated ability to plan experiments independently is desirable.

Education

  • BS with 2 years laboratory experience or MS with no experience with strong interest in contributing to the discovery of PROTAC molecules with drug-like properties in an innovative Pharma/Biotech environment.  Training in biophysical techniques is a plus and will be provided as needed.

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer   

Company

At Arvinas, we’re leading the creation of an entirely new way to treat disease through therapies that target and degrade disease-related proteins. We are a clinical-stage biopharmaceutical company focused on developing new therapeutics for cancers and other difficult-to-treat diseases. Our proprietary PROTAC® protein degraders, or proteolysis-targeting chimeras, work by harnessing the body’s own natural protein disposal system to degrade and remove disease-causing proteins.

Our leading programs are focused on high-value targets in cancer, including the androgen and estrogen receptors associated with prostate and breast cancers, respectively. Our hope is to unlock the full potential of PROTAC protein degradation by developing our own robust pipeline and by partnering with the world’s leading drug development companies.

QUALITY BENEFITS
Designed with health and wellness in mind, employees and their families are eligible for:

  • Medical, dental, and vision options, including a generous company contribution into an HSA
  • Paid maternity and paternity leave
  • FSA, HSA, Healthcare, and Dependent Care accounts
  • Company provided life insurance and short/long-term disability coverage
  • Additional voluntary benefits including critical illness, hospital care and more

COMPENSATION & EQUITY
Central to our organization is attracting, retaining and engaging the best and brightest by sharing in the success of our organization:

  • Competitive salaries and an annual incentive program
  • 401K matching program with immediate vesting
  • Eligibility for long-term equity incentives upon hire and annually

TIME OFF
We believe it’s important to relax, unwind and enjoy life’s moments:

  • Paid vacation
  • A year-end office closure
  • Observed company holidays
  • Paid sabbatical upon 5 years’ tenure

We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. We take our work very seriously, but we also ensure we’re having fun while doing it. We embrace the freedom to pursue innovation, think creatively, and give back. We care about each other, celebrate our accomplishments, and rise up to encourage our colleagues through challenges. If you think one of these open positions might be a fit, we’d love to hear from you.

Find Us
Website
Location
5 Science Park
395 Winchester Ave
New Haven
Connecticut
06511
United States
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