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Senior Principal Scientist, Molecular Pharmaceutics

La Jolla, California
Start date
Sep 28, 2022

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Science/R&D, Biotechnology
Required Education
Bachelors Degree
Position Type
Full time
Biotech Beach, Best Places to Work
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Job Details


The Senior Principal Scientist position is a scientific leadership role within the Molecular Pharmaceutics group in San Diego, California, responsible for early stage compound advancement and drug product strategy of new small molecules with a focus on the Oncology therapeutic area. The selected candidate will be scientifically grounded in fundamentals of pharmaceutical sciences, able to take on responsibilities of an individual contributor role in the advancement of both portfolio and scientific initiatives spaces, and show strong potential for growth into other areas of people and strategic leadership.


  • Strong understanding of the interconnectivity of molecular structure, phys/chem properties, biopharmaceutics, solid form, and formulation design
  • Application of fundamental physical chemistry knowledge in the area of small molecule behavior in solid state/solution/suspension
  • Efficient use of existing advanced modeling and simulation tools for predictive small molecule drug behavior; Advancement of fundamental concepts to improve predictive capabilities
  • Advancement of novel scientific research and both communication and application of findings


  • Collaborate with multi-disciplinary project teams to provide scientific leadership, strategic direction, and experimental support for the drug discovery of new Oncology small molecule candidates
  • Cultivate sustainable and effective relationships with internal partners and stakeholders, i.e., partner lines in PharmSci Small Molecule (PSSM), Clinical Pharmacology (ClinPharm), Drug Safety (DSRD), Oncology Research Unit (ORU), and Pharmacokinetics, Dynamics, and Metabolism (PDM)
  • Leverage existing knowledge, available tools and resources, and emerging science to develop guidance and recommendations on formulation, solid form, and biopharmaceutics aspects of pre-clinical and early clinical development
  • Advance scientific research with focus areas of deeper fundamental understanding and positioning the business for future capability. Present significant findings via internal and external presentations or publications.
  • Utilize scientific expertise to mentor and coach less-experienced colleagues


  • PhD in Pharmaceutics, Physical Chemistry, Chemical Engineering, or closely related discipline with 8-10 years relevant experience in oral absorption and small molecule drug product design, or BS/MS in Pharmaceutics, Physical Chemistry, Chemical Engineering or related discipline with a minimum of 12-15 years relevant pharmaceutics industry experience in small molecule drug product design.
  • Recognized expert in small molecule drug discovery/development with industry experience and a strong record of scientific achievement and project influence.
  • Experience in actively developing and advancing scientific initiatives and external collaborations.
  • A strong interest and motivation to learn and implement new technologies and concepts.
  • Extensive practical experience working within cross-disciplinary project teams and achieving results in a matrix environment.
  • Excellent organizational and communication (oral and written) skills.
  • Ability to work independently, as well as collaboratively.
  • Proven track record of mentoring and coaching junior scientists.

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.


  • Occasional travel may be required for in-person meetings, conferences, or project support.

Other Job Details:

  • Eligible for Employee Referral Bonus: YES


Relocation assistance may be available based on business needs and/or eligibility.

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development



Join world-class scientists and leaders who are dedicated to bringing therapies that will significantly improve patients' lives.

As one of the world's premier innovative biopharmaceutical companies, we're driven to discover the cure --driven to significantly improve the lives of everyone...everywhere. If you're similarly driven, you'll find there's no better place to begin --and continue --your career than at Pfizer.

Science is the foundation of our company.  This is why it's no surprise that the most driven scientists in the world choose to carry out their life's passion at Pfizer.  We arm them with the resources, technology, and facilities they need to solve some of the world’s most complex health challenges. This combination empowers our scientists with expertise in vaccines, small-molecule medicines, biotherapeutics amongst many others, to collaborate on breakthrough science, including the world's first mRNA-Based Covid19 vaccine.  Our colleagues advance science and technologies into the therapies that matter most.

Join us and you'll partner with colleagues of diverse backgrounds and abilities who contribute to all aspects of what we do. Great things happen when people come together with one shared goal. If you're driven to discover the cure- ensure it has the latest technology to make it a reality or help improve the lives of others- join those who are similarly driven at Pfizer. The future of medicine is happening here.

Visit and connect with us.



Find Us
(212) 733-2323
235 East 42nd Street
New York, NY 10017
United States
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