Scientist I

Who We Are:

We are an integrated genetic medicines company developing targeted, disease-modifying medicines for patients with life-limiting respiratory diseases. Our treatments address the underlying genetic cause in underserved populations and have the potential to tremendously impact the quality and length of patients’ lives.

At ReCode, we bring a unique blend of rigor, creativity, and curiosity to our high-hurdle mission: harnessing our multi-platform approach to develop disease-modifying medicines. Our team is uniquely positioned to tackle this challenge, given our extensive experience in RNA delivery technologies, protein structure, tRNA biology, mRNA manufacturing, gene editing, and drug development.

Summary of Position:

We are seeking a highly motivated and scientifically rigorous individual to join the Formulation and Delivery Discovery team. The position will focus on the development and application of experimental techniques to characterize and optimize delivery of novel LNP-formulations with diverse RNA cargos. The successful candidate will collaborate with an inter-disciplinary team of ReCode scientists and will have access to excellent experimental and analytical facilities.

Responsibilities:

• Producing lipid nanoparticle and polymeric formulations to support preclinical drug discovery and development efforts.

• Collaborate with other functions to execute and develop analytical methods to characterize formulations with diverse and mixed nucleic acid cargos.
• Work in collaboration with colleagues to identify optimal RNA formulation properties (composition, buffer, ionic strength, viscosity) for in vitro and in vivo drug delivery.
• Rational experimental planning and protocol writing. Collect data in (electronic) laboratory notebooks and provide data summaries.
• Prepare technical reports and presentations for clear communication of scientific findings across interdisciplinary teams.

• Communicate regularly with team members regarding project progress.
• Help mentoring junior team members.
• Contribute to lab management activities.

Qualifications:

• PhD in Chemistry/Physical Chemistry/Chemical Engineering/Biochemistry or related field. A strong background in non-viral delivery platforms is preferred.
• Hands-on experimental skills (e.g., experience in formulation and formulation characterization) with 3-6 years of relevant experience in drug delivery research
• Prior experience working with lipid nano particle delivery systems is strongly desired
• Proficiency in analytical techniques (HPLC/UPLC, DLS, CD, zeta potential, UV-Vis and fluorescence spectrophotometry)
• Direct experience with RNA product characterization/handling is preferred
• Thorough understanding of RNA-related analytics (Ribogreen, gel electrophoresis, capillary electrophoresis, etc.) is desirable
• Ability to maintain accurate and well-organized laboratory records
• Excellent organizational and oral/written communication skills
• Rigorous analytical, troubleshooting, and problem-solving skills
• Works independently as well as collaboratively within groups and interdisciplinary teams
• Desire to work in a fast-paced environment

ReCode Therapeutics (www.recodetx.com) offers a competitive compensation/benefits package with a friendly, collaborative culture that values employee engagement and ongoing career development.

ReCode Therapeutics is an Equal Opportunity Employer.