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Director, Quantitative Systems Pharmacology

Moderna, Inc.
Cambridge, MA
Start date
Sep 27, 2022

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Science/R&D, Pharmacology
Required Education
Position Type
Full time
Genetown, Best Places to Work
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Job Details

The Role:
The Director of quantitative systems pharmacology (QSP) modeling is a leadership position responsible for developing mechanistic modeling approaches to guide rigorous decision making from target identification to first-in-human studies and late-stage clinical development. The QSP group is embedded within the clinical pharmacology and pharmacometrics function at Moderna. We have a broad pipeline of vaccines and therapies across various disease areas including infectious diseases, rare diseases, autoimmune diseases, and oncology disorders. Modeling and simulation play an increasingly important role in decision making at Moderna. We are seeking a curious, collaborative, patient-focused and innovation-driven leader to frame critical questions and establish the right modeling & simulation strategies that enable lead optimization, inform dose selection and Go/No Go decisions

Heres What Youll Do:

  • Oversee, lead and review QSP model development efforts at various stages of R&D including target identification, first-in-human dose selection and beyound to enable accelerated/optimized advancement of mRNA platform technology and development candidates

  • Apply deep domain expertise to conceptualize mechanistic modeling approaches and provide model-based insights to guide R&D decisions

  • Identify critical capabilities and resource needs to achieve functional needs. Oversee CRO selections, mentorships, operational activities, build external consultant networks and set the right balance of internal versus external capabilities

  • Provide leadership in maintaining scientific awareness and presence in QSP modeling sciences, contribute to preparation of abstracts and manuscripts for publication

  • Strengthen our QSP capabilities on a continuous basis by evaluating and incorporating novel approaches and initiating trainings and mentorship programs as appropriate

  • Demonstrate drive, visibility and influence in key company decisions including advancement of mRNA platform technology, lead optimization, development candidate selection, patient dosage selection and clinical strategy

  • Actively contribute to a high-growth, transformational company that is Bold, Relentless, Curious, and Collaborative

Heres What Youll Bring to the Table:

  • PhD with a focus in pharmacokinetics, pharmacology, engineering, mathematics, or other related field with 7-12 years of drug development experience

  • Deep and broad experience in QSP and translational medicine with demonstrated efforts in influencing research and development of novel therapies

  • Demonstrated ability to identify key scientific questions related to R&D projects and ability to influence future advancements via applying mechanistic modeling and simulation approaches

  • Candidate will be curious in exploring new paths for model informed drug development. Will work collaboratively with multifunctional teams and will be relentless in pursuing successful outcomes

  • Proficient with modeling tools including Matlab/Simbiology, Julia/PUMAS, NONMEM, Monolix, R and Phoenix

  • Proficiency with systems modeling approaches such as differential equations, stochastic, logic, agent-based, neural ODEs or other advanced mechanistic modeling approaches is essential.

  • Knowledge of categorical data modeling approaches including logistic regression, Poisson regression, time-to-event models, discrete and continuous Markov chain models

  • Requires effective skills directed toward driving teamwork, accomplishing results, influencing, and solving problems across internal and external project teams

  • Understanding of data science and machine learning principles, including neural networks is a plus

  • Outstanding oral and written communication skills

Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:

  • Highly competitive and inclusive medical, dental and vision coverage options
  • Flexible Spending Accounts for medical expenses and dependent care expenses
  • Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities
  • Family care benefits, including subsidized back-up care options and on-demand tutoring
  • Free premium access to fitness, nutrition, and mindfulness classes
  • Exclusive preferred pricing on Peloton fitness equipment
  • Adoption and family-planning benefits
  • Dedicated care coordination support for our LGBTQ+ community
  • Generous paid time off, including:
    Vacation, sick time and holidays
    Volunteer time to participate within your community
    Discretionary winter shut down
    Paid sabbatical after 5 years; every 3 years thereafter
  • Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents
  • 401k match and Financial Planning tools
  • Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
  • Complimentary concierge service including home services research, travel booking, and entertainment requests
  • Free parking or subsidized commuter passes
  • Location-specific perks and extras!

Candidates should be aware that Moderna currently maintains a policy requiring all US-based employees to be fully vaccinated against COVID-19 and receive a booster shot once eligible. Newly hired employees must be vaccinated and boosted prior to their employment start date. Moderna is an equal opportunity employer and will provide a reasonable accommodation to those unable to be vaccinated or receive a booster where it is not an undue hardship to the company to do so as provided under federal, state, and local law.

About Moderna

In over 10 years since its inception, Moderna has transformed from a research-stage company advancing programs in the field of messenger RNA (mRNA), to an enterprise with a diverse clinical portfolio of vaccines and therapeutics across seven modalities, a broad intellectual property portfolio in areas including mRNA and lipid nanoparticle formulation, and an integrated manufacturing plant that allows for rapid clinical and commercial production at scale. Moderna maintains alliances with a broad range of domestic and overseas government and commercial collaborators, which has allowed for the pursuit of both groundbreaking science and rapid scaling of manufacturing. Most recently, Moderna's capabilities have come together to allow the authorized use and approval of one of the earliest and most effective vaccines against the COVID-19 pandemic.

Moderna's mRNA platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, and has allowed the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases, cardiovascular diseases and autoimmune diseases. Moderna has been named a top biopharmaceutical employer by Science for the past seven years. To learn more, visit

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a persons race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.




Moderna is advancing messenger RNA (mRNA) science to create a new class of transformative medicines for patients. Moderna’s platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, providing the Company the capability to pursue in parallel a robust pipeline of new development candidates. Moderna is developing therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases and cardiovascular diseases, independently and with strategic collaborators.

mRNA is now a turning point in the history of science, medicine, technology, even humankind itself. With this breakthrough discovery, many of the world’s biggest and most challenging medical problems are no longer a question of “how?” but merely a question of “when?”

Come with us as we pursue the uncharted reaches of possibility and make your mark on the future of medicine.


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Cambridge, MA
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