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Principal Scientist - Large Molecule Bioanalytical

Precision for Medicine
Frederick, Maryland (US)
DOE + full benefit package
Start date
Sep 26, 2022
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Job Details

Principal Scientist - Large Molecule Bioanalytical

The Principal Scientist supervises laboratory staff to support bioanalytical activities. Leads Bioanalysis and Biomarker projects through assay design and development, validation, and execution in a timely manner.  Performs assays according to SOPs and support technology development in Ligand Binding platform.


Essential functions of the job include but are not limited to:

  • Design and perform experiments, independently and accurately analyze and present data
  • Provide high quality output with the ability to build efficiency into improving productivity metrics
  • Serve as Technical Lead in Ligand Binding Platform
  • Assist in establishing and improving all procedures and required SOP documentation
  • Responsible for assay trouble shooting and correcting routine scientific issues/problems
  • Identify, update and implement emerging laboratory techniques
  • Maintain and support lab safety practices and environment
  • Work collaboratively with other technical teams in resource sharing and providing technical expertise
  • Support new equipment operational qualifications and performance checks
  • Monitor Lab Service/R&D related project expenses
  • Act as a scientific resource externally to clients and internally
  • Assists with writing, reviewing and editing contract and grant applications/proposals as appropriate
  • Assist with writing and publishing papers, abstracts, techniques/or chapters to maintain the scientific standard and image of the company.
  • May present completed work at appropriate scientific meetings and in publications
  • Supervision of assigned laboratory staff to ensure efficient organization, development and execution of project(s)
  • Other duties as assigned



Minimum Required:

  • Must have a Ph.D. in life sciences or relevant field in life sciences
  • At least 8 years of full-time post-doctoral laboratory experience

Other Required:

  • Strong background in various technology platforms such as Mesoscale Discovery, Quanterix, Luminex, ELISA.
  • Ability to troubleshoot and refine bioanalysis and biomarkers assays such as ADA, PK, Potency Assay, Cytokine and PD biomarker measurement
  • Experience in handling various sample matrix such as whole blood, plasma/serum, cell pellets/supernatant, urine and CSF
  • Excellent communication, interpersonal, and organizational skills required.
  • Must have the ability to organize and analyze data, as well as prepare technical reports.
  • Must possess strong computational skills, preferably experienced with Softmax, MSD BenchWork, Word, Excel, Power Point, GraphPad Prism
  • Excellent use of judgment and discretion required
  • Extended work hours may be occasionally necessary in order to meet business demands
  • Ability to lift and carry between 1-15 lbs.; Ability to lift up to 50 lbs. overhead with assistance; frequently required to sit, grasp, and use right/left finger dexterity; May be exposed to a cold freezer environment (Freezer temperatures range between -20ºC -196ºC)
  • Must be able to read, write, speak fluently and comprehend the English language




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