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Scientist, Upstream Process Development (South San Francisco, CA)

Employer
Sutro Biopharma, Inc
Location
South San Francisco, CA
Start date
Sep 25, 2022
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Job Details

Sutro Biopharma, Inc. is seeking a Scientist of Upstream Process Development who will participate in cross-functional teams and collaborate on multiple projects. Responsibilities include ensuring the smooth operation of Sutro’s novel cell-free protein synthesis process (XpressCF™) and working with multiple groups in R&D to improve product titers and product quality by examining the biochemical and physical factors affecting cell-free performance and scale-up. The production process for Sutro’s cell-free extract (XtractCF™), including spray drying, may also be investigated for improvements and robustness. Experiments are conducted over a large range of scales using a variety of techniques, including high throughput screening and large scale (kL) production. Work may also include technology transfer to internal and/or external Manufacturing sites. This position will also collaborate with the product pipeline PD group as candidate products move through clinical trials including late-stage trials and possibly commercialization.

Responsibilities

The successful candidate will design and execute cell-free protein synthesis experiments and develop new methods/techniques as needed. Two major foci of the position will be expanding the biochemical understanding of XpressCF™ and improving process performance for both titer and product quality. In addition, the successful candidate will be required to make presentations to internal teams and senior management and to author internal and external publications.

Qualifications

We are seeking a highly motivated team-player with excellent problem-solving skills and experience with bioprocesses and microbial metabolism. Versatility is a must, as tasks will involve a range of reactors and scales and process modes. Good organizational skills and the ability to manage tasks within a timeline are essential.

The ideal candidate will have the following background/skill set:

  • Ph.D. with 2 to 5 years of industry experience or M.S./B.S. with 7 to 10 years of experience in Chemical Engineering, Bioengineering, Biochemistry, or a related discipline.

Experience with the following is required:

  • Laboratory scale process equipment, especially bioreactors for microbial and/or mammalian culture.
  • Bioprocess development (cell-free, microbial, and/or mammalian cell-based).

Experience with the following is preferred:

  • Cell-free protein synthesis.
  • Spray drying macromolecules (proteins, nucleic acids, and/or liposomes).
  • Metabolite/biochemical assays (HPLC and/or microtiter plate based).
  • Design of Experiments.
  • cGMP bioprocessing.

Sound exciting? Apply today and join our team!

Sutro Biopharma, Inc. requires all new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Sutro will consider requests for reasonable accommodations.

Sutro provides a competitive benefits package that includes a choice of health, dental, and vision insurance, life insurance, flexible spending accounts, 401K plan, PTO, ESPP (Employee Stock Purchase Plan) and stock options.

As an equal opportunity employer, we believe in fostering a culture that is inclusive and values diversity in background and opinions. Sutro Biopharma hires extraordinary individuals into every position in the company and is committed to the diversity of our team. Our company progresses without regard of race, ethnicity, gender, sexual orientation, religious belief, age, disability or citizenship status. We are dedicated to creating a safe environment where our employees can grow and succeed together.

Salaries listed on jobsites may not be representative of salary ranges at Sutro Biopharma.

We look forward to hearing from candidates who are interested in exploring opportunities with Sutro! Our People & Culture team/hiring managers are unable to respond and do not accept solicitations from third-party agencies.

Company Overview

Sutro Biopharma, Inc., located in South San Francisco, is a clinical-stage drug discovery, development and manufacturing company. Using precise protein engineering and rational design, Sutro is advancing next-generation oncology therapeutics.

Sutro is dedicated to transforming the lives of cancer patients by creating medicines with improved therapeutic profiles for areas of unmet need. To date, Sutro’s platform has led to cytokine-based immuno-oncology therapies, ADCs, vaccines and bispecific antibodies directed at precedented targets in clinical indications where the current standard of care is suboptimal.

The platform allows it to accelerate discovery and development of potential first-in-class and best-in-class molecules through rapid and systematic evaluation of protein structure-activity relationships to create optimized homogeneous product candidates.

In addition to developing its own oncology pipeline, Sutro is collaborating with select pharmaceutical and biotech companies to discover and develop novel, next-generation therapeutics. As the pace of clinical development accelerates, Sutro and its partners are developing therapeutics designed to more efficiently kill tumors without harming healthy cells.

Company

Sutro Biopharma, Inc., headquartered in South San Francisco, is a clinical-stage oncology company pioneering site-specific and novel-format antibody drug conjugates (ADCs). Sutro has two wholly owned ADCs in the clinic—STRO-002, a folate receptor alpha (FolRα)-targeting ADC, in clinical studies for ovarian and endometrial cancers; and STRO-001, a CD74-targeting ADC, in clinical studies for B-cell malignancies.

Additionally, Sutro is collaborating with Bristol Myers Squibb (BMS) on CC-99712, a BCMA-targeting ADC in the clinic for patients with multiple myeloma; with Merck KGaA, Darmstadt, Germany, known as EMD Serono in the U.S. and Canada (EMD Serono), on M1231, a MUC1-EGFR bispecific ADC in clinical studies for patients with solid tumors, particularly non-small cell lung cancer (NSCLC) and esophageal squamous cell carcinoma; with Merck, known as MSD outside of the United States and Canada, on MK-1484, a selective IL-2 agonist in clinical studies as a monotherapy and in combination with pembrolizumab for the treatment of solid tumors; and with Astellas Pharma (Astellas) on novel modality, immunostimulatory antibody-drug conjugates (iADCs). Sutro’s platform technology also enabled the spin out of Vaxcyte (Nasdaq: PCVX) and the creation of VAX-24, a 24-valent pneumococcal conjugate vaccine in clinical studies for the prevention of invasive pneumococcal disease. Sutro’s rational design and precise protein engineering has enabled six product candidates in the clinic.

Sutro is dedicated to transforming the lives of cancer patients by creating medicines with improved therapeutic profiles for areas of unmet need. To date, Sutro’s platform has led to ADCs, bispecific antibodies, cytokine-based immuno-oncology therapies, and vaccines directed at precedented targets in clinical indications where the current standard of care is suboptimal.

The platform allows it to accelerate discovery and development of potential first-in-class and best-in-class molecules through rapid and systematic evaluation of protein structure-activity relationships to create optimized homogeneous product candidates. In addition to developing its own oncology pipeline, Sutro is collaborating with select pharmaceutical and biotech companies to discover and develop novel, next-generation therapeutics.

Follow Sutro on Twitter, @Sutrobio, and at www.sutrobio.com to learn more about our passion for changing the future of oncology.

Stock Symbol: STRO

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Find Us
Website
Phone
650.881.6500
Location
111 Oyster Point Blvd
South San Francisco
California
94080
United States
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