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Co-Op, Analytical Development

Entrada Therapeutics
Boston, MA
Start date
Sep 22, 2022

View more

Information Technology, Business/Data Analytics
Required Education
Bachelors Degree
Position Type
Full time
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Job Details

The Organization

What’s happening at Entrada Therapeutics? Our mission is to transform the treatment of devastating diseases and improve patients’ quality of life using intracellular biologics. Leveraging our proprietary Endosomal Escape Vehicle (EEV)TM platform, we are creating and advancing a diverse pipeline of oligonucleotide, enzyme, protein and peptide programs to efficiently target and engage underlying drivers of diseases. Our novel approach to drug design and delivery addresses current challenges associated with both large and small molecule therapeutics and represents a fundamental advancement in the field of intracellular biologics.

We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease and are excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The Perfect Fit

You should be a highly motivated and collaborative Co-Op in our analytical development group. The successful candidate will have a degree in chemistry or related field and be responsible for the analysis of oligonucleotides/peptides/conjugates, routine equipment maintenance, writing procedures, documenting experiments and inventory management. The candidate will join interdisciplinary team of scientists aiming to develop innovative medicines for treating some of the most challenging diseases.

You should also enjoy a fast-paced environment and juggling competing priorities. You follow up and follow through, connecting problems with solutions efficiently. You work successfully in a team environment with strong interpersonal skills to effectively build working relationships inside and outside the company.

The Opportunity

In this role, you will be responsible for the operation and routine maintenance of LCMS to support the discovery chemistry and process development groups. You will be overseeing these instruments for characterization, and purity determination of prepared compounds. You will support the development of analytical methods of oligonucleotides, peptides, conjugates, and small molecules.

  • Operation and routine maintenance of LCMS
  • Preparation of LC buffers
  • Documentation of the testing samples and results
  • Collecting and reviewing of experimental results, interpretation of data
  • Generation of experiment reports and delivery of the reports to customers
The Necessities

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

Humanity- We genuinely care about patients and about one another

Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients

Creativity- We are creative problem solvers

Collaboration- We are more than the sum of our parts

Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

  • Your BS/MS with industry or academic research experience will have you ready to perform at your best
  • Previous experience with chromatography techniques: HPLC, MS, or LCMS are preferred
  • Any understanding or experience with oligonucleotide chemistry is highly desirable as well as the knowledge of analytical chemistry of oligonucleotides
  • An understanding and knowledge of lab safety, organic chemistry reactions, and mechanisms is required
  • To be effective on our team, you must have the ability to interact effectively in a multi-disciplinary, fast-paced research environment as well as the ability to multi‐task to meet research and development goals
The Perks

By becoming a co-op at Entrada, you’ll be eligible for a commuter expense reimbursement and paid holidays. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.


Entrada Therapeutics is a biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines, Endosomal Escape Vehicle (EEV™) therapeutics, to engage intracellular targets that have long been considered inaccessible and undruggable. The Company’s EEV therapeutics are designed to enable the efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues with an improved therapeutic index. Through its proprietary, highly versatile and modular EEV platform, Entrada is building a robust development portfolio of oligonucleotide-, antibody- and enzyme-based programs for the potential treatment of neuromuscular diseases, immunology, oncology and diseases of the central nervous system. The Company’s lead oligonucleotide programs include ENTR-601-44 targeting Duchenne muscular dystrophy (DMD) and ENTR-701 targeting myotonic dystrophy type 1 (DM1).

Stock Symbol: TRDA
Stock Exchange: NASDAQ



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6 Tide Street
United States
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