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DMPK Scientist

Arvinas Inc.
Working from Home
Start date
Sep 21, 2022

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Science/R&D, Biotechnology, Pharmacokinetics
Required Education
Position Type
Full time
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Job Details

Arvinas is a clinical-stage biopharmaceutical company leading the way in targeted protein degradation therapeutics. Arvinas is the first company to focus solely on protein degradation and its platform technology is the most advanced in the field. Since its founding in 2013, Arvinas’ PROTAC® Discovery Engine has been driving the most significant breakthroughs in the industry. Arvinas’ pipeline encompasses a range of validated and undruggable targets in oncology, immuno-oncology, and neuroscience. This includes three clinical-stage programs: bavdegalutamide (ARV-110) and ARV-766, which are being developed as potential treatments for men with late-line metastatic castrate-resistant prostate cancer, and ARV-471, which is being developed as a potential treatment for patients with breast cancer.

#TeamArvinas is made up of more than 350 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and purpose – to improve the well-being of patients and families impacted by the devastating diseases Arvinas is working to treat. It’s an exciting time to be in drug development and it’s an exciting time to be at Arvinas. But don’t just take our word for it – here’s what Arvinas employees are saying. For more information, please visit


Position Summary

We have an exciting opening for an experienced DMPK scientist. The incumbent will contribute as a DMPK scientist on project teams from drug discovery through all stages of drug development, with a scientific background on several aspects of DMPK science, including but not limited to in vitro and in vivo ADME, bioanalysis, animal PK, toxicokinetic, drug metabolism, DME- and transporter-based DDI, 14C-ADME studies, QWBA, human PK prediction, PKPD modeling and simulation, PBPK.    

This position reports to the Head of Nonclinical Science and may be based at our headquarter location in New Haven, CT or a remote role based within the U.S.


Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Serve as a DMPK scientist and advise discovery teams on strategies for early ADMET profiling up to the selection of lead candidate into development.
  • Represent DMPK function on company-wide development teams to support the advancement of preclinical and clinical assets.
  • Contribute to the in vitro DDI and other in vitro/in vivo DMPK assessment for individual preclinical drug candidates and ensure timely availability of key data as part of the IND enabling activities.
  • Recommend stage appropriate clinical DDI strategy to the clinical pharmacology function. 
  • Contribute to outsource of DMPK studies and ensure timely and high quality conduct of in vitro and in vivo ADMET studies. Partner with key CROs to develop and customize ADMET assays to support PROTAC drug discovery and development.
  • Contribute to the preparation of DMPK component of regulatory documents such as IND, IB, or other documents.
  • Stay up to date with the scientific advance and regulatory landscape for DMPK science in drug discovery and development


  • In-depth knowledge or expertise on one or several other aspects of DMPK science in drug discovery and/or development, such as biotransformation, bioanalysis, pharmacokinetics, toxicokinetics, DME- and transporter-based drug-drug interaction, PBPK or PK/PD modeling, human PK prediction.
  • General knowledge of drug discovery and development process.
  • Experience in representing DMPK on discovery and development teams.
  • Ability to integrate DMPK knowledge of individual drugs and prepare DMPK components of regulatory documents.
  • Hands-on experience and proficiency in PK/PD modeling, PBPK modeling with PK or modeling software such as Phoenix and GastroPlus would be highly desirable.
  • Knowledge of relevant regulatory guidance in areas such as drug-drug interaction, bioanalysis, and GLP.


  • Ph.D. in pharmaceutical science, chemistry, biochemistry, or related scientific discipline with five-plus years of relevant experience in DMPK in the biopharmaceutical industry or CROs supporting pharmaceutical development, preferably with a focus on small molecules.




Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit

Arvinas is an Equal Opportunity employer   


At Arvinas, we’re leading the creation of an entirely new way to treat disease through therapies that target and degrade disease-related proteins. We are a clinical-stage biopharmaceutical company focused on developing new therapeutics for cancers and other difficult-to-treat diseases. Our proprietary PROTAC® protein degraders, or proteolysis-targeting chimeras, work by harnessing the body’s own natural protein disposal system to degrade and remove disease-causing proteins.

Our leading programs are focused on high-value targets in cancer, including the androgen and estrogen receptors associated with prostate and breast cancers, respectively. Our hope is to unlock the full potential of PROTAC protein degradation by developing our own robust pipeline and by partnering with the world’s leading drug development companies.

Designed with health and wellness in mind, employees and their families are eligible for:

  • Medical, dental, and vision options, including a generous company contribution into an HSA
  • Paid maternity and paternity leave
  • FSA, HSA, Healthcare, and Dependent Care accounts
  • Company provided life insurance and short/long-term disability coverage
  • Additional voluntary benefits including critical illness, hospital care and more

Central to our organization is attracting, retaining and engaging the best and brightest by sharing in the success of our organization:

  • Competitive salaries and an annual incentive program
  • 401K matching program with immediate vesting
  • Eligibility for long-term equity incentives upon hire and annually

We believe it’s important to relax, unwind and enjoy life’s moments:

  • Paid vacation
  • A year-end office closure
  • Observed company holidays
  • Paid sabbatical upon 5 years’ tenure

We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. We take our work very seriously, but we also ensure we’re having fun while doing it. We embrace the freedom to pursue innovation, think creatively, and give back. We care about each other, celebrate our accomplishments, and rise up to encourage our colleagues through challenges. If you think one of these open positions might be a fit, we’d love to hear from you.

Find Us
5 Science Park
395 Winchester Ave
New Haven
United States
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