Associate Director, Oncology Translational Biomarker Lead

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science.In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

When you join BMS, you are joining a diverse, high-achieving team united by a common mission.

The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies and transforming response and durability rates for cancer patients. Comprising of scientists across multiple disciplines we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies.

We are seeking a highly motivated and experienced individual with deep translational expertise to join the Translational Development team within the Tumor Microenvironment Thematic Research Center (TME TRC) at Bristol Myers Squibb in Redwood City, CA.

In this role as Associate Director, Translational Biomarker Lead, within the TME TRC Translational Development team, the ideal candidate:

• Designs, develops, establishes, and executes well-crafted asset-level oncology translational plans and biomarker strategies for First In Human through Proof of Concept studies within the TME TRC, focused on mechanism of action, target engagement and pharmacodynamic biomarker assays and potential clinical trial patient stratification and selection assays.

• Accountable for creation and analysis of the assay development and clinical sample analysis plans, budgets and data, such as generating validation plans and study reports, developing SOPs, reviewing validation reports, and contributing to and reviewing all pertinent documentation for assigned programs in collaboration with relevant internal subject matter experts

• Effectively partners within a highly matrixed organization within the Translational Development group, within the TME TRC, with oncology program colleagues & with external partners to deliver high-quality biomarker data and drive the advancement of therapeutic candidates.

• Integrates discovery, translational research and other relevant assay information and data, along with logistics and quality considerations, to inform highly complex ideas, activities, and projects.

• Accountable for providing scientific input and biomarker expertise across all aspects of early development plans and collaborations (such clinical protocols, sample collection tables, sample collection instructions and logistics, scopes of work, data transfer agreements, validation reports, study reports, central lab logistics, posters, publications, investigator brochures, INDs, regulatory documents, etc.)

• Progresses translational plans into implementation and execution via leading Translational Subteams, monitoring and tracking assay and analysis status and deliverables, via collaboration with internal technical assay execution and/or execution with external contract research organizations (CROs) and/or specialty testing laboratories

• Supports due diligence, collaboration and asset integration activities

• Proactively provides insight into novel ways to incorporate biomarkers into clinical designs to enable early understanding of emerging drug profiles, as well as input around tumor types and potential impact of biomarkers on internal decision making.

• Provides oversight to progress validated biomarkers into development of diagnostic assays, as needed

• Participates in strategic review and input to presentations, publications and internal/ external communications along with accountable program leadership and in governance forums

• Develops solutions and courses of action for senior staff, including identification of risks and risk mitigations

• Shares expertise, experience, lessons learned and knowledge with translational and other relevant scientific experts and colleagues across the organization

Basic Qualifications:

• Bachelor’s Degree and 12+ years of academic and / or industry experience

OR

• Master’s Degree and 10+ years of academic and / or industry experience

OR

• Ph.D. or equivalent advanced degree in the Life Sciences and 8+ years of academic and / or industry experience

PLUS

• 4+ years of leadership experience

Preferred Qualifications:

• MD, PhD or MD/PhD or equivalent advanced biology degree with industry experience in the drug development process, preferred within oncology translational biomarker roles and with solid tumor and immune oncology experience

• Experience from FIH through at least phase 2 trials, including directly contributing to clinical translational and biomarker components of study protocols, laboratory manuals, investigator brochures, regulatory documents, and INDs

• Experience interfacing with clinical teams and presenting at strategic meetings, and demonstrated ability to lead and influence others in a highly matrixed work environment

• Working knowledge of all functional areas of drug development, including, biology, toxicology, clinical development, diagnostic development, etc

• Demonstrated scientific acumen and mechanistic understanding of disease biology and experience in oncology and immuno-oncology drug development (small molecule and biologics)

• Excellent communication skills and comfortable working in a fast-paced environment where speed is paramount

• Experience in the design, execution and generation of clinical trial translational biomarker assays and data in oncology across multiple technologies and sample types (e.g. genomics, immunohistochemistry, flow cytometry, immunoassay and other technologies) in various stages of clinical development

• Ability to effectively collaborate with internal and external partners

• Comfortable working in a fast-paced environment

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Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

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