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Director, Statistical Genetics

Employer
Maze Therapeutics
Location
South San Francisco, CA
Start date
Sep 18, 2022

View more

Discipline
Science/R&D, Genetics
Required Education
Doctorate/PHD/MD
Position Type
Full time
Hotbed
Biotech Bay

Job Details

About Maze Therapeutics

Maze is a clinical-stage biopharmaceutical company harnessing the power of human genetics to transform the lives of patients through the development of a pipeline of novel precision medicines for patients with genetically defined diseases. Maze is leveraging Compass™, a proprietary, end-to-end purpose built platform to advance a pipeline of precision medicines across four disease areas - renal, cardiac, neurological and metabolic diseases. Our flexible business model aims to translate our genetic insights into new therapies for patients as possible.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients. 

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.  

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others. 

Stand True – Our integrity is foundational; it guides us no matter the obstacle. 

 

Role Description:

We are seeking an exceptional leader in statistical genetics to join our Translational Genomics team. The successful candidate will design, lead and/or execute robust genetic association studies with the goal of identifying potential drug targets. In addition to performing analyses on large-scale genetic datasets, the statistical genetics team will integrate results from functional genomics experiments to complement allelic series grounded on known human genetic variants. Successful candidates will contribute directly to the development of novel disease modifying therapeutics. The role requires experience managing high-performing teams of scientists and strong analytical skills with an ability to collaborate with biologists and other data scientists.

Your Impact Includes:

  • Leverage major scientific and technological advances, including investment in biobanks linked to large-scale human health databases, cutting-edge informatics platforms, breakthrough understanding of biological pathways and functional genomics capabilities 
  • Identify internal and external collaboration opportunities in the human genetics space
  • Identify and integrate data tools to expand analysis capabilities and maintain an up-to- date understanding of statistical genetics capabilities 
  • Perform and interpret human genetic analyses using public and internal data to identify new targets and therapeutic hypotheses
  • Work in close collaboration with human genetics and functional genomics to integrate results from functional genomics studies with human genetics data for new target identification/prioritization 
  • Oversee and foster an internal team as well as external collaborations in the human genetics space
  • Contribute to writing patents, reports and scientific publications 

Qualifications:

  • Ph.D. with significant relevant experience in human genetics/statistical genetics/bioinformatics and the biologic interpretation of human genetic data
  • 8+ years of research experience, preferably in increasing responsibility. Industry experience required
  • Strong communication and interpersonal skills 
  • Demonstrated ability to lead a team of statistical geneticists 
  • Well versed in the management, curation, and analysis of large (n>50,000) exome or whole-genome sequence datasets such as Geisinger, UK Biobank, TopMed, Gnomad, and others. 
  • Experience in the analysis of large-scale genomic association studies in complex genetic diseases including identifying and removing most common sources of technical noise using cloud-enabled tools. 
  • Strong computational/statistical skills (coding in Hail, python, R)
  • Strong connecting skills to drive early research forward and collaborate with later stage teams in development programs
  • A highly motivated disposition and desire to push new scientific boundaries

Company

Maze Therapeutics is translating novel genetic insights into lifesaving medicines, through an approach that integrates human genetics and functional genomics. Advances in these areas have enabled us to decode the mysteries of genetic modifiers in a range of severe diseases, which we aim to turn into medicines that mimic protective mutations. 
 
What are genetic modifiers?
 
Despite an understanding of the genetic basis for many diseases, it remains a mystery why some people with a disease-causing mutation never get sick. This is often due to genes elsewhere in our DNA that affect the severity of disease and can provide a natural form of protection.
 
The Maze approach
 
Dramatic advances in human genetics and functional genomics now enable us to decode the mysteries of genetic modifiers in a range of severe diseases. Today, we believe we can systematically identify genetic modifiers and turn these insights into medicines. We have assembled a world-class team to realize this vision, including creative scientific pioneers, experienced company builders and biotech industry leaders.
 
Join us in our pursuit to change lives by translating genetic insights into medicine - view our job postings with the link to the left.

Company info
Website
Location
171 Oyster Point Blvd, Suite 200
South San Francisco
CA
94080
United States

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