Principal Scientist - Downstream Process Development

Synthorx, a Sanofi Company, has advanced a revolutionary technology that expands the genetic alphabet to drive the site-specific incorporation of multiple non-natural amino acids into proteins of any size, and to manufacture these improved proteins at scale. This technology opens up opportunities to make novel protein therapeutics to previously difficult to drug targets; more information can be found at: https://www.sanofi.com/en/science-and-innovation/research-and-development/technology-platforms/synthorin-technology-platform

We are seeking a Principal Scientist to join our Downstream Process Development team. Reporting to the Head of CMC, this individual will lead a team that is responsible for developing innovative, robust, efficient, and scalable purification processes for a diverse set of biologics which incorporate the Synthorin™ noncanonical amino acid technology. This will encompass development of primary recovery, refolding, purification, conjugation, filtration, and formulation operations.

This individual will take a leading role in designing and performing downstream process development and scale-up activities. Additionally, this individual will be involved in training and mentoring team members as well as authoring technical documents (reports, tech transfer documents, SOPs) and presenting data to key stakeholders. This individual will provide strong technical, strategic, and organizational leadership, effectively manage multiple projects, and make strong technical and strategic contributions to cross-functional project teams.

Key Responsibilities:

• Develop robust, high yield, and scalable downstream processes for refolding, purification, and filtration of expressed proteins, within aggressive timelines.

• Manage and mentor a team of scientists. Ability to plan and resource effectively.

• Prepare and review technical documents including development reports and tech transfer packages.

• Experience with managing contract service providers and technology transfer.

• Provide technical guidance and training to co-workers in the execution and analysis of downstream processes and in the use of current and new equipment.

• Proactively troubleshoot and mitigate complex technical, experimental, and instrumental issues.

• Consummate ability to work in a highly collaborative, fast-paced, cross-functional environment, with superior oral and written communication skills.

Basic Qualifications:

• Ph.D. degree in related field with 3+ years of experience or a MS degree with 5+ years of experience, or a BS degree with 8+ years of experience.

• Hands-on experience in developing and executing methods for protein purification.

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Preferred Qualifications:

• Experience with high throughput purification (HTP) strategies and refolding of proteins from inclusion bodies

• Hands-on experience with AKTA instrumentation is required. Strong background in protein purification is essential. Experience with various modes of chromatography (IEX, HIC, RPC, SEC, affinity)

• Experience with filtration (TFF, ultrafiltration / diafiltration)

• Experience in protein characterization methods (SDS-PAGE, HPLC, CGE, endotoxin)

What makes this position unique?

• Synthorx’s novel platform + Sanofi’s pipeline and resources = Limitless therapeutic potential!

• Small company biotech culture within a bigger pharmaceutical company.

• Highly dynamic and collaborative environment.

Benefits of working in this role:

• Opportunities to grow within a rapidly expanding multinational company.

• Benefit of being part of a larger company: vast resources, including mentoring programs and professional development resources.

• Synthorx and Sanofi company-wide recognition systems.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.

According to the CDC, an individual is considered to be “fully vaccinated” fourteen (14) days after receiving (a) the second dose of the Moderna or Pfizer vaccine, or (b) the single dose of the J&J vaccine. Fully vaccinated, for new Sanofi employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE.

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