The RGC’s Genome Informatics team is looking for the Director of Sequencing Informatics Research is the lead scientist and developer for the RGC’s Sequencing Informatics research initiatives. As both an individual contributor and developer, this individual will conceive of and develop novel sequencing informatics methods (including base-calling, demultiplexing, read mapping and alignment, variant calling) for new and existing multi-omics platforms, including Ultima, Illumina, PacBio, Olink. Working closely with the Sequencing & Lab Operations and Production Informatics teams, you will lead the methods engagement with RGC’s technology partners to onboard new sequencing and informatics platforms and ensure they can meet our unique scaling and analysis needs.
In this role, a typical day might include the following:
Innovate novel sequencing informatics methods to support multi-omics applications on existing and new sequencing platforms, including DNA-seq, RNA-seq, long-read sequencing, and proteomics.
Lead RGC’s joint development efforts with technology partners (e.g. NVIDIA, Google Brain) to improve base-calling, read mapping, variant calling and harmonization through algorithm development, bioinformatics R&D, and hardware acceleration.
Collaborate with the Engineering and Production teams to deploy novel methods into the Enterprise Research environment as industry-quality software.
Find opportunities to address genomics privacy topics (e.g. anonymization, data federation) through sequencing informatics solutions in data storage, encryption/compression, decomposed algorithms and information querying
Work closely with Regeneron IP and Legal departments to make innovative methods available to RGC’s research partners and the broader research community.
This job might be for you if:
You have an interest in the health & life-sciences data domain.
You have a passion to bring innovative technologies in the field.
You are thorough and focus on the quality of the final product.
You enjoy collaborating with multi-functional teams of scientists, analysts, and engineers.
With your sleeves rolled up, you work on current problems while thinking of future solutions.
To be considered for this role you must have a PhD or equivalent experience in Computer Science or Bioinformatics. Demonstrated history of developing novel methods adopted by the bioinformatics community. Mastery of sequencing informatics methodology, including base calling, read mapping, and variant calling algorithms and software. Experience with large-scale multi-omics data types, including DNA-seq (short and long read), RNA-seq, proteomics, methylation. Expert fluency in pioneering bioinformatic tools and standards. Demonstrated engagement in the sequencing bioinformatics community. Experience optimizing sequencing informatics methods for speed and cost through software and hardware acceleration. Experience creating or adapting novel bioinformatic data structures and file formats to improve actionability
Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.